Strategic approaches to developing drug treatments for ALS

Drug Discovery Today
Andrea M VincentE L Feldman

Abstract

Significant progress in understanding the cellular mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) has not been matched with the development of therapeutic strategies to prevent disease progression. The multiple potential causes and relative rarity of the disease are two significant factors that make drug development and assessment in clinical trials extremely difficult. We review recent progress in promoting therapeutics into clinical trials and highlight the value of moderate throughput screening for the acceleration and improvement of drug design.

Citations

Mar 5, 2009·Disease Models & Mechanisms·Dagmar E EhrnhoeferMichael R Hayden
Oct 7, 2008·Brain : a Journal of Neurology·Claudia PitzerArmin Schneider
Dec 8, 2010·Expert Opinion on Therapeutic Targets·Magdalena Kuzma-Kozakiewicz, Hubert Kwiecinski
Feb 11, 2016·Drug Discovery Today·Pascaline ClercCatherine Willett
Sep 6, 2011·Neurobiology of Disease·Thais Federici, Nicholas M Boulis
Jul 1, 2010·Cytotherapy·Josep GamezInmaculada Bori-Fortuny
Mar 25, 2015·Trends in Neurosciences·Eliot A Brenowitz, Harold H Zakon
Jul 1, 2016·Expert Review of Neurotherapeutics·Svitlana Garbuzova-DavisPaul R Sanberg
May 24, 2019·Journal of Translational Medicine·William R SwindellJohn J Kopchick

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