Strategic locus for the activation of the superoxide dismutase gene in the nephron

Kidney International
S KiyamaI Ichikawa

Abstract

Upon exposure to a transient ischemia, the distal tubule of the kidney often escapes the severe damage which afflicts the proximal tubule. To ascertain whether this feature of the distal tubule is attributable to its intrinsic cellular properties, we focused on two pairs of unique tubule segments; distal versus proximal convoluted tubules in the superficial cortex and distal versus proximal straight tubules in the outer stripe of the outer medulla. These tubules were chosen because, firstly, they can be identified by morphology and immunostaining, and secondly, each pair has the same anatomical relationship to the circulation. Detailed morphometric analyses were performed six hours following unilateral transient ischemia in adult rats to semiquantitate the local tissue damage in these specific nephron segments. The architecture of the distal convoluted and straight tubules was remarkably well preserved, contrasting to the moderate to extensive necrotic changes seen in the proximal tubules. In search of the potential intrinsic cellular mechanism that underlies the observed difference, we examined the segmental distribution along the nephron of manganese superoxide dismutase gene transcripts by in situ hybridization. This antioxi...Continue Reading

References

Nov 30, 1977·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·W J MergnerB F Trump
Nov 2, 1976·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J I KreisbergR B Nagle
Sep 1, 1976·The American Journal of Medicine·K Thurau, J W Boylan
Dec 1, 1992·The American Journal of Physiology·T D NolandM D Breyer
Jun 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S N HeymanS Rosen
Jan 1, 1991·Free Radical Biology & Medicine·J K BeckmanH L Greene
Mar 1, 1991·American Journal of Respiratory Cell and Molecular Biology·Y S HoJ D Crapo
Aug 1, 1990·Kidney International·T YoshiokaI Ichikawa
Mar 31, 1989·Biochemical and Biophysical Research Communications·S SugiyamaT Ozawa
Feb 1, 1988·The Journal of Clinical Investigation·P D Walker, S V Shah
May 1, 1986·Kidney International·P F ShanleyS Rosen
Oct 1, 1984·Kidney International·M BrezisF H Epstein
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Jan 1, 1980·The International Journal of Biochemistry·W Pfaller, M Rittinger
Jan 1, 1994·Kidney International·T YoshiokaI Ichikawa
Dec 1, 1993·Journal of the American Society of Nephrology : JASN·B BraamL G Navar
Jun 1, 1993·Kidney International·Y KakinumaI Ichikawa
Aug 1, 1993·Kidney International·L LiuJ E Bourdeau

❮ Previous
Next ❯

Citations

Sep 21, 2000·Kidney International. Supplement·M Dunlop
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·L A MacMillan-CrowJ A Thompson
Aug 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert L ChevalierBarbara A Thornhill
Jun 17, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sibel BayrakAyse Nur Cakar
Sep 21, 2012·Kidney International·Andrew M HallBruce A Molitoris
May 12, 1998·The Journal of Physiology·W GwinnerC J Olbricht
Apr 11, 2017·The Journal of Veterinary Medical Science·Orapun JaturakanChollada Buranakarl
Jan 18, 2008·Journal of the American Society of Nephrology : JASN·Robert L Chevalier, Michael S Forbes
Feb 20, 2015·American Journal of Physiology. Renal Physiology·Carolina I GalarretaRobert L Chevalier
Jun 7, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Wei GuoRichard A Cohen
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·Chiang-Ting ChienSu-Ming Hsu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.