Strategies and prospects of effective neural circuits reconstruction after spinal cord injury.

Cell Death & Disease
Biao YangQixin Chen

Abstract

Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous economic and emotional burdens were brought to society and family. Despite many strategies being dealing with SCI, there is still no effective regenerative therapy. To date, significant progress has been made in studies of SCI repair strategies, including gene regulation of neural regeneration, cell or cell-derived exosomes and growth factors transplantation, repair of biomaterials, and neural signal stimulation. The pathophysiology of SCI is complex and multifaceted, and its mechanisms and processes are incompletely understood. Thus, combinatorial therapies have been demonstrated to be more effective, and lead to better neural circuits reconstruction and functional recovery. Combinations of biomaterials, stem cells, growth factors, drugs, and exosomes have been widely developed. However, simply achieving axon regeneration will not spontaneously lead to meaningful functional recovery. Therefore, the formation and remodeling of functional neural circuits also depend on rehabilitation exercises, such as exercise training, electrical stimulation (E...Continue Reading

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Citations

Jan 6, 2021·International Journal of Molecular Sciences·Esther GiraldoVictoria Moreno-Manzano
Jan 19, 2021·Molecular Biology Reports·Akram Tayanloo-BeikBagher Larijani
Dec 24, 2020·Journal of Neurotrauma·Leslie R MorseUNKNOWN SCI 2020 Working Group
Nov 1, 2020·International Journal of Molecular Sciences·Sara De VincentiisVittoria Raffa
Mar 5, 2021·Reviews in the Neurosciences·Graham Ka Hon SheaKenneth Man Chee Cheung
Mar 16, 2021·Emergent Materials·Amene Saghazadeh, Nima Rezaei
Mar 26, 2021·Brain : a Journal of Neurology·Masao KodaMasashi Yamazaki
Jul 17, 2021·Neural Regeneration Research·Joseph A FlackJennifer Yanhua Xie

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