Strategies for a multi-stage neutralizing antibody-based HIV vaccine

Current Opinion in Immunology
Raiees AndrabiDennis R Burton

Abstract

A critical property of a prophylactic HIV vaccine is likely to be its ability to elicit broadly neutralizing antibodies (bnAbs). BnAbs typically have multiple unusual features and are generated in a fraction of HIV-infected individuals through complex pathways. Current vaccine design approaches seek to trigger rare B cell precursors and then steer affinity maturation toward bnAbs in a multi-stage multi-component immunization approach. These vaccine design strategies have been facilitated by molecular descriptions of bnAb interactions with stabilized HIV trimers, the use of an array of sophisticated approaches for immunogen design, the development of novel animal models for immunogen evaluation and advanced technologies to interrogate antibody responses. In this review, we will discuss leading HIV bnAb vaccine immunogens, immunization strategies and future improvements.

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Citations

Dec 19, 2018·Nature Reviews. Immunology·Dennis R Burton
Dec 17, 2019·Immunological Reviews·Roos M de JongTeun Bousema
Apr 4, 2020·Emerging Microbes & Infections·Qian WangLinqi Zhang
Apr 29, 2020·Annual Review of Immunology·Kathryn E StephensonDan H Barouch
May 21, 2019·Current Opinion in HIV and AIDS·Irene A AbelaAlexandra Trkola
Jan 2, 2021·Frontiers in Pediatrics·Tulika SinghSallie R Permar
Dec 2, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stefanie ThalhauserMiriam Breunig
Feb 11, 2021·Vaccines·Zekun MuDerek W Cain
Feb 15, 2020·Current Opinion in Biotechnology·Jocelyne Tremouillaux-GuillerAbdullah Makhzoum
Dec 6, 2020·Seminars in Immunology·Simone PecettaAnja Seubert
Apr 16, 2021·Cell Host & Microbe·Elise Landais, Devin Sok
Jan 22, 2021·Physical Biology·Arvind MuruganNigel Goldenfeld

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