Strategies for antiviral resistance in transgenic plants.

Molecular Plant Pathology
M PrinsMark Tepfer

Abstract

Genetic engineering offers a means of incorporating new virus resistance traits into existing desirable plant cultivars. The initial attempts to create transgenes conferring virus resistance were based on the pathogen-derived resistance concept. The expression of the viral coat protein gene in transgenic plants was shown to induce protective effects similar to classical cross protection, and was therefore distinguished as 'coat-protein-mediated' protection. Since then, a large variety of viral sequences encoding structural and non-structural proteins were shown to confer resistance. Subsequently, non-coding viral RNA was shown to be a potential trigger for virus resistance in transgenic plants, which led to the discovery of a novel innate resistance in plants, RNA silencing. Apart from the majority of pathogen-derived resistance strategies, alternative strategies involving virus-specific antibodies have been successfully applied. In a separate section, efforts to combat viroids in transgenic plants are highlighted. In a final summarizing section, the potential risks involved in the introduction of transgenic crops and the specifics of the approaches used will be discussed.

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Citations

Oct 22, 2010·Journal of Virology·Jason KerkvlietMoses Rodriguez
Dec 18, 2010·BMC Biotechnology·Zun Liu, Christopher M Kearney
Jun 2, 2012·Silence·Cheng-Guo DuanHui-Shan Guo
Jan 1, 2014·PloS One·Marjorie RomonJean E Masson
May 14, 2014·PloS One·Hongyan GuoRongxiang Fang
Dec 1, 2015·Frontiers in Microbiology·Chao ZhangJianguo Wu
Dec 4, 2015·PLoS Pathogens·Meghan M PainterMoses Rodriguez
Dec 3, 2014·Plant Science : an International Journal of Experimental Plant Biology·Leny C GalvezAmitava Mitra
Feb 26, 2016·Journal of Virological Methods·Henry WagabaNigel J Taylor
Feb 9, 2017·Frontiers in Microbiology·Gustavo Romay, Claude Bragard
May 21, 2018·Plant Cell Reports·Kul Bhushan
Sep 16, 2018·Viruses·Maathavi KannanHamidun Bunawan
Dec 23, 2020·International Journal of Molecular Sciences·Sandeep Kaur DhaliwalPrashant Kaushik
Jun 3, 2021·Viruses·Richard KormelinkCecile Desbiez

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