PMID: 3320539Jan 1, 1987Paper

Strategies for breast cancer therapy with antiestrogens

Journal of Steroid Biochemistry
V C JordanM M Gottardis

Abstract

Current clinical research is focused upon the application of adjuvant therapy for the treatment of breast cancer. Combination chemotherapy is the most successful adjuvant therapy for premenopausal patients whereas the antiestrogen tamoxifen (1 or 2 yr) is successful in postmenopausal disease. We have developed a unifying strategy for the treatment of breast cancer. The thesis is based upon the application of continuous adjuvant therapy with tamoxifen in a low estrogen environment. Chemotherapy causes a chemical castration in premenopausal patients. In contrast, tamoxifen causes an increase in steroidogenesis. A combination of both approaches will work against each other until ovarian failure occurs. Patients should be checked for castration to provide a low estrogen environment in which tamoxifen, a competitive antagonist of estrogen action, can effectively work. Laboratory evidence using carcinogen-induced rat mammary tumor models demonstrates the efficacy of long-term therapy. Studies with the human breast cell line MCF-7 grown in athymic mice show that tamoxifen is a tumoristatic agent so that once the therapy is stopped, tumors can be regrown by estrogen administration. Patients should receive continuous tamoxifen therapy t...Continue Reading

References

Aug 1, 1979·The Journal of Clinical Investigation·B M ShermanD Wycoff
Feb 1, 1976·The Journal of Endocrinology·V C Jordan, L J Dowse
Jul 1, 1976·Acta Pathologica Japonica·M KuriharaK Suzuki
Aug 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R I Nicholson, M P Golder
Jun 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V C Jordan
Sep 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M P GolderK Griffiths
Mar 1, 1976·The Journal of Endocrinology·V C Jordan, T Jaspan
Aug 23, 1986·Lancet·N PadmanabhanR D Rubens
Mar 1, 1986·Journal of Surgical Oncology·H KashtanM Krispin
Jan 27, 1968·Nature·E M Pantelouris
Oct 23, 1980·Nature·K D SetchellM Axelson
Jan 1, 1984·Breast Cancer Research and Treatment·D C Tormey, V C Jordan
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·S HelgasonB von Schoultz
Jul 2, 1981·The New England Journal of Medicine·B FisherH Shibata

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Citations

Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·R B DicksonM E Lippman
Mar 4, 2011·Endocrine-related Cancer·Chellappagounder ThangavelErik S Knudsen
Dec 1, 1988·European Journal of Cancer & Clinical Oncology·S P RobinsonV C Jordan
Dec 1, 1993·Critical Reviews in Oncology/hematology·S K ChanderY A Luqmani
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R W PeroW Troll
Feb 1, 1989·European Journal of Cancer & Clinical Oncology·N KnebelE von Angerer
Oct 1, 1987·Immunology and Cell Biology·G F Mitchell, E Handman
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·V C JordanW V Welshons

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