Strategies for control of zidovudine concentrations in serum.

Antimicrobial Agents and Chemotherapy
S E NoormohamedC V Fletcher

Abstract

There are several clinical scenarios in which knowledge of zidovudine disposition may be important. This study evaluated the clinical utility of pharmacokinetic parameters for zidovudine derived from sparse serum concentration data obtained in an outpatient setting. Twelve human immunodeficiency virus-infected participants had two serum zidovudine concentrations determinations obtained on two different clinic visits, 2 to 38 days apart. Zidovudine concentrations were measured by radioimmunoassay. A one-compartment oral absorption model was used to describe zidovudine disposition. Three different approaches were used to estimate pharmacokinetic parameters: Bayesian estimation with one or two concentrations and least squares with one concentration. The ability of these parameters to predict concentrations measured during the second clinic visit was assessed by calculation of precision and bias and compared with predictions using standard fixed or weight-adjusted parameters. Estimated pharmacokinetic parameters for zidovudine were consistent with literature values; there was no statistically significant difference among the parameters calculated with the three estimation strategies. Absorptive phase concentrations were poorly pred...Continue Reading

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Citations

Mar 1, 2003·Current Therapeutic Research, Clinical and Experimental·Robert E ArianoSheryl A Zelenitsky
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·T N KakudaC V Fletcher
Dec 16, 2005·The AAPS Journal·Leslie A KennaMarc Pfister
May 25, 2005·Clinical Pharmacokinetics·Jeffrey S BarrettMarc Pfister
Feb 27, 2003·Fundamental & Clinical Pharmacology·Patrinee SasomsinFrançoise Brun-Vezinet
Oct 3, 1998·Clinical Pharmacology and Therapeutics·C V FletcherH H Balfour

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