Strategies for glucose control in a study population with diabetes, renal disease and anemia (Treat study)

Diabetes Research and Clinical Practice
Larry A WeinrauchJanet B McGill

Abstract

Glucose lowering medication use among patients with type 2 diabetes and advanced renal disease (eGFR<60) in a large multinational outcome trial (TREAT) is assessed. We demonstrate statistically significant differences regionally in use of metformin at lower eGFR and increasing reliance upon insulin with/without other medications at low eGFR. As renal disease advances, most of the oral anti-diabetic agents requiring renal clearance must be reduced or discontinued. The potential for prolonged hypoglycemia, fluid/volume overload and congestive heart failure may complicate medication choices. In order to evaluate patterns of glycemia management we describe glucose lowering medication use among patients with advanced renal disease and type 2 diabetes in a large multinational outcome trial designed to focus on patients with eGFR<60 in order to commence a dialog on best practices. We felt that analysis of this data would be able to describe regional variations in treatment within a multinational trial in order to understand potential outcome differences attributed to complications. The patients entering this study had moderate glycemic control. Insulin therapy either alone (32%) or in combination with other agents (17%) reflected a sh...Continue Reading

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Citations

Mar 5, 2016·The Journal of Clinical Hypertension·Larry A WeinrauchJohn A D'Elia
May 14, 2016·The Journal of Clinical Hypertension·Larry A WeinrauchJohn A D'Elia
Jun 18, 2016·Journal of the American College of Cardiology·Larry A WeinrauchJohn A D'Elia
Feb 6, 2017·Journal of the American Geriatrics Society·John A D'EliaLarry A Weinrauch

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