Strategies for identifying pregnancies in the automated medical records of the General Practice Research Database

Pharmacoepidemiology and Drug Safety
Janet R HardyMichael B Bracken

Abstract

To develop a method for identifying the beginning and ending records of pregnancies in the automated medical records of the General Practice Research Database (GPRD). Women's records from 1991 to 1999 were searched for codes from 17 pregnancy marker and 7 pregnancy outcome categories. Using the retrieved records, all possible pregnancy marker-outcome combinations were formed per woman. For each combination, the difference in days between record event dates was calculated. Restrictions were applied to select the combination with the earliest pregnancy marker mapped to the first outcome for each pregnancy. Iterations of the algorithm identified multiple pregnancies per woman when present. The algorithm was evaluated by analyzing time between marker and outcome event dates of mapped pregnancies and by analyzing unmapped pregnancy markers and outcomes. A total of 297,082 pregnancies were identified: 80% by general practitioner (GP) visit codes as the earliest pregnancy marker and 14% by laboratory or procedure codes. Limiting pregnancies to one per woman aged 15-44 years yielded 209,266 pregnancies. Pregnancy mapping success was greater than 80%. Plotting the pregnancies by weeks from earliest pregnancy marker to outcome and by pre...Continue Reading

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Citations

Dec 19, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Leif I SolbergPatricia F Walker
Apr 21, 2012·Emerging Infectious Diseases·Salaheddin M MahmudLawrence Elliott
Nov 26, 2008·American Journal of Preventive Medicine·Leif I SolbergA Lauren Crain
Jul 3, 2013·Pharmacoepidemiology and Drug Safety·Lucia Cea-SorianoSonia Hernández-Díaz
Jun 5, 2013·Pharmacoepidemiology and Drug Safety·R T MikolajczykE Garbe
Mar 23, 2010·Pharmacoepidemiology and Drug Safety·Sarah E McDowellR E Ferner
Oct 14, 2009·Pharmacoepidemiology and Drug Safety·Scott DevineAndrew Olshan
Apr 3, 2015·Pharmacoepidemiology and Drug Safety·Lockwood G TaylorTrinka Coster
Dec 22, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rachel A CharltonJohn G Weil
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Jul 6, 2019·BMJ Health & Care Informatics·Harshana LiyanageSimon de Lusignan
Mar 5, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·H KitherI Crocker
Jun 15, 2019·Pharmacoepidemiology and Drug Safety·Caroline MinassianSara L Thomas
Jan 30, 2015·Pharmacoepidemiology and Drug Safety·Andrea V MargulisSonia Hernández-Díaz

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