PMID: 7993562Jun 1, 1994Paper

Strategies for improving the assessment of dental fluorosis: focus on chemical and biochemical aspects

Advances in Dental Research
T Aoba


In order to assess fluoride accumulation and effects in developing dental tissues, one must determine the concentration profile of fluoride in the tissue and to assess separately the labile (i.e., free ions in fluid and ions associated with organic matter) and stable (i.e., incorporated into apatite lattice) pools of fluoride. Free fluoride ions in the mineralizing milieu markedly affect the driving force for precipitation and, as a result, the nature of precipitating crystals. The fluoride incorporated into the crystalline lattice increases the stability of the formed mineral. Improvement in the understanding of the mechanism of dental fluorosis requires more comprehensive information about the effects of fluoride on the ionic composition of the fluid phase, the nature of the initially precipitating mineral(s), the interactions between crystals and matrix proteins, and the enzymatic degradation of the proteins. Recent observations relevant to the role of fluoride in enamel formation include: (1) that there are threshold concentrations of fluoride below which the precipitation and hydrolysis of thin-platy octacalcium phosphate is facilitated but beyond which de novo apatite precipitation prevails; (2) that the presence of fluor...Continue Reading


Mar 1, 1979·Journal of Dental Research·M ShimizuM Fukae
Jan 1, 1977·Caries Research·J A WeatherellA S Hallsworth
Dec 29, 1977·Calcified Tissue Research·M J GlimcherP T Levine
Jan 1, 1992·Caries Research·A RichardsO Fejerskov
Dec 1, 1991·Journal of Dental Research·S ShimodaE C Moreno
Dec 1, 1990·Calcified Tissue International·T Aoba, E C Moreno
Jun 1, 1990·Calcified Tissue International·T Kawamoto, M Shimizu
Dec 1, 1985·Journal of Dental Research·P K DenbestenM H Wilson
Sep 1, 1989·Advances in Dental Research·A RichardsV Baelum
Sep 1, 1989·Advances in Dental Research·T YanagisawaO Fejerskov
Jan 1, 1989·Archives of Oral Biology·J CarterM G Shepherd
Jan 1, 1989·Archives of Oral Biology·P K DenBesten, L M Heffernan
Jun 1, 1989·The Anatomical Record·C E SmithA Nanci
Jan 1, 1986·Journal of Dental Research·J W BawdenT G Deaton
Dec 1, 1986·Journal of Dental Research·A RichardsO Fejerskov
Jan 4, 1974·Nature·E C MorenoR T Zahradnik
May 1, 1974·Archives of Oral Biology·M Fukae, M Shimizu
Jan 1, 1984·Calcified Tissue International·E C MorenoD I Hay
Jan 1, 1984·Caries Research·B Angmar-Månsson, G M Whitford
May 1, 1984·Journal of Dental Research·J W Bawden, M A Crenshaw
Jan 1, 1984·Archives of Oral Biology·P K DenBesten, M A Crenshaw
Jan 1, 1981·Calcified Tissue International·K Varughese, E C Moreno
Feb 1, 1988·Journal of Dental Research·R A FridellJ W Bawden

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Nov 4, 2000·Connective Tissue Research·S J BrookesC Robinson
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