Strategies for intervention with chemopreventive agents

International Journal of Cancer. Journal International Du Cancer
M Lipkin

Abstract

Different mechanisms of activity have led to the development of a wide variety of intermediate biomarkers to measure the efficacy of chemopreventive agents. Chemopreventive agents are now being used in pre-clinical models that have targeted mutations or normal cells. Based on pre-clinical findings, clinical chemoprevention studies have progressed to measure the possible modulation of dysplastic lesions, including adenomas. Human studies are best carried out where the study design matches the known activity of the agents on cells in early, mid- or late stages of abnormal cellular development, previously determined in pre-clinical studies.

References

Sep 6, 1995·Journal of the National Cancer Institute·M Lipkin, H Newmark
Feb 1, 1994·Cell Structure and Function·R WadhwaY Mitsui
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·R FoddeP M Khan
Sep 30, 1995·Annals of the New York Academy of Sciences·M Lipkin

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Citations

Jan 1, 1996·Journal of Cellular Biochemistry. Supplement·M LipkinR Kucherlapati

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