Strategies for optimizing the phase correction algorithms in Nuclear Magnetic Resonance spectroscopy

Biomedical Engineering Online
Franciszek BinczykJoanna Polanska

Abstract

Nuclear Magnetic Resonance (NMR) spectroscopy is a popular medical diagnostic technique. NMR is also the favourite tool of chemists/biochemists to elucidate the molecular structure of small or big molecules; it is also a widely used tool in material science, in food science etc. In the case of medical diagnosis it allows for determining a metabolic composition of analysed tissue which may support the identification of tumour cells. Precession signal, that is a crucial part of MR phenomenon, contains distortions that must be filtered out before signal analysis. One of such distortions is phase error. Five popular algorithms: Automics, Shanon’s entropy minimization, Ernst’s method, Dispa and eDispa are presented and discussed. A novel adaptive tuning algorithm for Automics method was developed and numerically optimal solutions to automatic tuning of the other four algorithms were proposed. To validate the performance of the proposed techniques, two experiments were performed - the first one was done with the use of in silico generated data. For all presented methods, the fine tuning strategies significantly increased the correction accuracy. The highest improvement was observed for Automics algorithm, independently of noise level...Continue Reading

References

Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J R RoebuckT Raidy
Jun 30, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D HernandoS B Reeder
Feb 27, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amir MoussaviJens Frahm
Jul 16, 2013·Journal of Magnetic Resonance·Qingjia BaoChaoyang Liu
Jan 18, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jamie NearPeter Jezzard
Feb 4, 2014·Chemometrics and Intelligent Laboratory Systems : an International Journal Sponsored by the Chemometrics Society·Bradley Worley, Robert Powers

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Citations

Sep 4, 2015·Biomedical Engineering Online·Franscisco M OrtuñoIgnacio Rojas

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Methods Mentioned

BETA
NMR

Software Mentioned

Dispa
Automics
eDispa
Ernst

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