Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosis.

Cellular & Molecular Biology Letters
Joel N H Stern, Derin B Keskin

Abstract

Multiple sclerosis (MS) is a chronic, debilitating disease, which manifests itself by de-myelination of the central nervous system (CNS). MS is predominantly found in Caucasians of European decent and is more prominent in females than males. MS is one of the most prevalent causes of disability of young adults in the world. The exact cause of MS is not known, however genetic susceptibility to MS is linked to the major histocompability complex (MHC). Self reactive CD4+ T cells, specific for CNS antigens, such as myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP), are detectable in MS patients along with pathogenic autoantibodies specific to these CNS antigens produced by B cells. These observations suggest that MS is an autoimmune disease. Epidemiology of MS along with the analysis of sibling pairs and twins suggest that the multiple genetic factors and their interaction with environment contribute to disease susceptibility. Recent developments and advancements in genetic analysis may aid in accurate determination of genetic risk factors for the development of MS. We review these developments, advances in technology and discuss recent results in this article.

References

Apr 10, 1976·British Medical Journal·G DeanJ Tallett-Williams
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R Chakraborty, K M Weiss
Mar 1, 1988·American Journal of Medical Genetics·A D SadovnickR H Ward
Feb 1, 1982·Neurology·J F KurtzkeS Bergmann
Sep 13, 1996·Science·N Risch, K Merikangas
Mar 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C P Genain, S L Hauser
Mar 10, 2001·Nature·R SachidanandamUNKNOWN International SNP Map Working Group
Jun 22, 2001·Trends in Genetics : TIG·R C Jansen, J P Nap
Oct 5, 2001·Nature Genetics·M J DalyE S Lander
Mar 21, 2003·Nature·Eric E SchadtStephen H Friend
Aug 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zsolt IllésVijay K Kuchroo
Aug 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joel N H SternJack L Strominger
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Joel N H SternJack L Strominger
Apr 6, 2005·Veterinary Immunology and Immunopathology·Dirk-Jan de KoningChris S Haley
Nov 1, 2005·European Journal of Immunology·Zsolt IllesJack L Strominger
Jan 24, 2007·Nature Medicine·Kevin C O'ConnorKai W Wucherpfennig
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Jul 31, 2007·Nature Genetics·Simon G GregoryUNKNOWN Multiple Sclerosis Genetics Group
Nov 7, 2007·The Journal of Experimental Medicine·Barbara SerafiniFrancesca Aloisi
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joel N H SternJack L Strominger

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Citations

Jul 28, 2012·Journal of Molecular Neuroscience : MN·Pawel LisowskiArtur H Swiergiel
May 25, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·C Oreja-GuevaraE Díez-Tejedor

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