Strategies for the Total Synthesis of Clavicipitic Acid

Chemistry : a European Journal
Mamoru ItoTakanori Shibata

Abstract

Clavicipitic acid is an ergot alkaloid, which was isolated from Claviceps strain and Claviceps fusiformis. Its unique tricyclic azepinoindole skeleton has attracted synthetic chemists, and various strategies have been developed for its total synthesis. These strategies can be generally categorized into two types based on the synthetic intermediates, namely, 4-substituted gramine derivatives and 4-substituted tryptophan derivatives. This Minireview summarizes the reported total syntheses from the point of these two key intermediates.

References

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Jul 17, 2015·Chemistry : a European Journal·Yu-ki TaharaTakanori Shibata

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Citations

May 25, 2016·Organic & Biomolecular Chemistry·Stephanie R McCabe, Peter Wipf
Jun 24, 2017·Chemistry : a European Journal·Marino Petrini
Oct 26, 2016·Organic & Biomolecular Chemistry·F BartocciniG Piersanti
Nov 8, 2017·Chemical Communications : Chem Comm·Jin-Quan ChenXiao-Ping Cao
Jun 23, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Tetsuhiro Nemoto
Jul 20, 2018·Natural Product Reports·Ashley C LindsayJonathan Sperry
Mar 17, 2017·Natural Product Reports·Haichao Liu, Yanxing Jia
Jul 5, 2016·Chemical & Pharmaceutical Bulletin·Takaaki KubotaJun'ichi Kobayashi
Apr 4, 2020·Organic Letters·Kuan-Lin ChenHsiao-Ching Lin
May 24, 2019·The Journal of Organic Chemistry·Francesca BartocciniGiovanni Piersanti
Nov 18, 2020·The Journal of Organic Chemistry·Yi HeErik V Van der Eycken

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