Strategies for treatment to prevent fragility fractures in postmenopausal women

Best Practice & Research. Clinical Rheumatology
Piet P M M Geusens

Abstract

The objective of treatment of osteoporosis is to decrease the risk of fractures in patients at high risk for a first or subsequent fracture. The efficacy of treatment will depend on the efficiency and level of implementation of clinical case finding to select patients at risk, the results of additional investigations, the efficacy, tolerance and safety of medical intervention and the adherence to treatment during follow-up. Each of these steps is critical in treatment in daily practice. Failure to consider one or another step can result in suboptimal fracture prevention or overtreatment. The aim of case finding is to identify patients for treatment, who have disease characteristics of patients in whom fracture prevention has been demonstrated in randomised controlled trials (RCTs). These include patients with a low-trauma hip or vertebral fracture, with a low bone mineral density (BMD) or with a high risk of fracture based on the presence of clinical risk factors (CRFs) for osteoporosis and fractures such as included in the FRAX case-finding algorithm, with or without BMD. Case finding starts clinically, with systematic or opportunistic doctor- and/or patient-driven evaluation for the presence of CRFs, but its implementation is...Continue Reading

References

Jul 11, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T ChevalleyR Rizzoli
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Cara TannenbaumMarjorie Luckey
Sep 23, 2003·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Sep 23, 2003·The New England Journal of Medicine·Joel S FinkelsteinRobert M Neer
Nov 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Alastair R McLellanCarol McQuillian
Apr 9, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P D DelmasC Christiansen
May 26, 2004·Archives of Internal Medicine·Ethel S SirisMarc L Berger
Jun 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L S Morrison, J H Tobias
Oct 27, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisAlan Tenenhouse
Nov 27, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Dana BliucJacqueline R Center
Dec 2, 2004·Journal of the National Cancer Institute·Silvana MartinoUNKNOWN CORE Investigators
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Clarita V OdvinaCharles Y C Pak
Feb 25, 2005·QJM : Monthly Journal of the Association of Physicians·T-P van StaaC Cooper
May 11, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Marc C HochbergUNKNOWN FIT Research Group
Jul 20, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Robert P Heaney
Aug 12, 2005·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Aug 12, 2005·The New England Journal of Medicine·Felicia CosmanRobert Lindsay
Nov 10, 2005·JAMA : the Journal of the American Medical Association·Laufey SteingrimsdottirGunnar Sigurdsson
Nov 22, 2005·Drugs·Mishaela R Rubin, John P Bilezikian
Dec 27, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Svenhjalmar van HeldenPiet Geusens
Jan 25, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D H SolomonJ N Katz
Jul 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ego SeemanSteven Boonen
Jul 13, 2006·Annals of the New York Academy of Sciences·R Graham G Russell
Dec 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H A Bischoff-Ferrari
May 1, 2007·Bone·Heike Annette Bischoff-Ferrari, Bess Dawson-Hughes
May 4, 2007·The New England Journal of Medicine·Steven R CummingsDennis M Black
Jul 25, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel H SolomonJerry Avorn
Aug 22, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E Michael LewieckiUNKNOWN AMG 162 Bone Loss Study Group
Sep 11, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roland D ChapurlatPierre D Delmas
Nov 29, 2007·JAMA : the Journal of the American Medical Association·Dawn C MackeyUNKNOWN Study of Osteoporotic Fractures (SOF) and Osteoporotic Fractures in Men Study (MrOS) Research Groups
Jan 9, 2008·Bone·John A KanisNikolai Khaltaev
Feb 28, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Piet GeusensGeert Jan Dinant
Apr 3, 2008·Current Medical Research and Opinion·Fernie J A Penning-van BeestRon M C Herings
Apr 10, 2008·Nature Clinical Practice. Rheumatology·Piet P GeusensMarc C Hochberg
Apr 30, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·John T SchousboeNeil Binkley
Jun 12, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M Lewiecki, N B Watts
Jun 12, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Díez-Pérez, J González-Macías
Aug 6, 2008·BMC Musculoskeletal Disorders·Bianca DumitrescuPiet Geusens
Oct 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Véronique RabendaJean-Yves Reginster
Dec 5, 2008·Nutrition Reviews·Robert P Heaney

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Citations

Jun 22, 2010·Current Osteoporosis Reports·Joop P W van den BerghPiet P Geusens
Nov 26, 2010·Maturitas·Mark BrincatUNKNOWN EMAS
Jun 9, 2017·Journal of Aging and Physical Activity·Katie CrockettCatherine M Arnold
Feb 3, 2015·The Journal of Rheumatology·Shirley L ChowUNKNOWN Canadian Rheumatology Association Choosing Wisely Committee
Mar 29, 2012·Menopause : the Journal of the North American Menopause Society·Rafael Lomas-VegaAntonio Martínez-Amat
Apr 23, 2013·International Journal of Endocrinology·Nicole YurginMarc Hochberg
Aug 13, 2010·Current Opinion in Supportive and Palliative Care

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