PMID: 9419447Jan 7, 1998Paper

Strategies for tumor elimination by cytotoxic T lymphocytes

Critical Reviews in Immunology
L A ShermanJ Biggs

Abstract

Despite differences in their tissue of origin, many tumors share high level expression of certain tumor-associated proteins. Our laboratory has focused on the possibility of utilizing antigenic components of these proteins as a focus for T-cell immunotherapy of cancer. The advantage of targeting such commonly expressed proteins is the fact that such therapy could be of value in eliminating many different types of tumors. A potential barrier in the identification of T-cell epitopes derived from these proteins and presented by tumor cells is the fact that these proteins are also expressed at low levels in some normal tissues, and therefore, self-tolerance may eliminate T cells that are capable of recognizing these epitopes with high avidity. We have utilized two different murine model systems to explore the extent to which self-tolerance may limit the immune response to a tumor-specific antigen. The first compared the ability of mice deficient in expression of murine p53 (p53 knock-out mice) and normal mice, to respond against several epitopes of the p53 protein. The second model compares the ability of conventional mice with transgenic mice that express the influenza hemagglutinin in the periphery to respond to a dominant antige...Continue Reading

Citations

Jan 16, 2007·Cancer Immunology, Immunotherapy : CII·Guang-Yun SongJoshua D I Ellenhorn
May 31, 2001·Vox Sanguinis·J L SchultzeR H Vonderheide
Oct 26, 1999·Immunobiology·M Zöller, S Matzku
Jan 18, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Helmut Borberg
Oct 25, 2002·Cytotherapy·J D Gordan, R H Vonderheide
Nov 5, 2002·Nature Biotechnology·Michael H KershawPatrick Hwu
Aug 10, 2010·Nature Medicine·Liang-Ping LiThomas Blankenstein
Oct 16, 2001·Drugs & Aging·S Matzku, M Zöller
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A RosenbergSeth M Steinberg
Jan 5, 2002·Physiological Reviews·Brigitte Lankat-Buttgereit, Robert Tampé
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J HernándezL A Sherman
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E M HiltboldO J Finn
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J HernándezL A Sherman
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaoyun ZhuHing C Wong
Dec 3, 1999·Biochimica Et Biophysica Acta·R Abele, R Tampé

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