Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles

Biochimie
Aqeel AhmadShafiul Haque

Abstract

Nanoparticles (NPs) are one of the leading and promising technologies for gene and drug delivery. However, despite continuous advancements in the delivery of NPs, endosomal escape remains a major issue and a matter of grave concern for developing an efficient and targeted delivery system for therapeutic applications. Most of NPs generally follow endocytic pathway for internalization into the cells. Following the internalization process, NPs must escape into the cell cytoplasm for evading degradation by hydrolytic enzymes present in the lysosomes. Various types of lipids have been used in the past viz. fusogenic lipid dioleoylphosphatidylethanolamine (DOPE), pH-sensitive lipids, cationic lipid and multiple charges containing lipid to escape from endosomes. Recently, several novel polymers, pH-sensitive peptides, proteins and many others endosomolytic agents have been identified and developed for incorporating into gene and drug delivery system to facilitate endosomal escape. In this review, endosomal escape mechanisms of different types of NPs have been discussed in detail and compared with endosomal escape mechanisms of viruses and other synthetic gene delivery systems to escape from endosomes. Also, the designing of endosomoly...Continue Reading

Citations

Mar 11, 2020·Pharmaceutics·Catarina Roma-RodriguesAlexandra R Fernandes
Sep 8, 2020·Pharmaceutical Development and Technology·Yordan YordanovKrassimira Yoncheva
Sep 26, 2020·International Journal of Molecular Sciences·Ruslan KashapovOleg Sinyashin
Jan 18, 2020·Current Pharmaceutical Design·Mohammad A AnsariNiyaz Ahmad
Dec 16, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Kangkang AnChao Lin
Jan 16, 2021·Drug Discovery Today·Bilal Ahamad ParayMohammad Z Ahmed
Apr 16, 2020·Acta Biomaterialia·Waqas NawazZhiwei Wu
Aug 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Huang YangZhengwei Mao
Mar 23, 2021·Advanced Drug Delivery Reviews·Michaela Schulz-Siegmund, Achim Aigner
Apr 3, 2021·International Journal of Pharmaceutics·Aqeel AhmadSanjeev Ranjan
Mar 7, 2020·Biochimica Et Biophysica Acta. Biomembranes·Sébastien DeshayesPrisca Boisguérin
Jun 4, 2021·ACS Biomaterials Science & Engineering·Jose Antonio Duran-MotaNuria Oliva
Aug 10, 2021·Molecular Aspects of Medicine·Alysia CoxEun Ji Chung
Aug 11, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meenu MehtaKamal Dua
Aug 11, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Saurabh ShahSaurabh Srivastava
Aug 22, 2021·Biotechnology Advances·Hèctor López-LagunaUgutz Unzueta
Aug 28, 2021·International Journal of Molecular Sciences·Shabnam TarvirdipourCornelia G Palivan
Sep 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shin YanagiharaAtsushi Harada

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