Strategies in Translating the Therapeutic Potentials of Host Defense Peptides.

Frontiers in Immunology
Darren Shu Jeng TingImran Mohammed

Abstract

The golden era of antibiotics, heralded by the discovery of penicillin, has long been challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides (HDPs), previously known as antimicrobial peptides, are emerging as a group of promising antimicrobial candidates for combatting AMR due to their rapid and unique antimicrobial action. Decades of research have advanced our understanding of the relationship between the physicochemical properties of HDPs and their underlying antimicrobial and non-antimicrobial functions, including immunomodulatory, anti-biofilm, and wound healing properties. However, the mission of translating novel HDP-derived molecules from bench to bedside has yet to be fully accomplished, primarily attributed to their intricate structure-activity relationship, toxicity, instability in host and microbial environment, lack of correlation between in vitro and in vivo efficacies, and dwindling interest from large pharmaceutical companies. Based on our previous experience and the expanding knowledge gleaned from the literature, this review aims to summarize the novel strategies that have been employed to enhance the antimicrobial efficacy, proteolytic stability, and cell selectivity, which are al...Continue Reading

References

Nov 1, 1992·International Journal of Peptide and Protein Research·D WadeR B Merrifield
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T P Creamer, G D Rose
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D WadeR B Merrifield
Jul 1, 1990·Clinical Microbiology Reviews·A P JohnsonR C George
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H V WesterhoffM Zasloff
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ZasloffH C Chen
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Zasloff
Aug 29, 1988·FEBS Letters·H C ChenC M Huang
Oct 6, 1993·Biochimica Et Biophysica Acta·S E BlondelleR A Houghten
Jun 26, 1997·Nature·J HarderJ M Schröder
Jan 8, 1999·Drugs·H M Lamb, L R Wiseman
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·Y GeM Zasloff
Apr 9, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·S Y ShinK S Hahm
May 5, 1999·Nature·K PütsepS Normark
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·H Yan, R E Hancock
Jul 27, 2001·Nature·S Fernandez-LopezM R Ghadiri
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monisha G ScottRobert E W Hancock
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Magdalena Sieprawska-LupaJan Potempa
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew E Falagas, Sofia K Kasiakou
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Dawn M E BowdishRobert E W Hancock
Jul 26, 2005·Nature Biotechnology·Kai HilpertRobert E W Hancock
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Véronique DartoisThomas R Parr
Oct 25, 2006·Antimicrobial Agents and Chemotherapy·Randal EckertWenyuan Shi
Dec 13, 2006·Nature Biotechnology·Robert E W Hancock, Hans-Georg Sahl
Jun 6, 2007·Journal of Medicinal Chemistry·Rickey P HicksAlan J Magill
Jul 25, 2007·BMC Bioinformatics·Sneh LataG P S Raghava
Aug 19, 2007·Current Opinion in Immunology·Alfredo Menendez, B Brett Finlay
Nov 13, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Marcia Perez Dos Santos CabreraJoão Ruggiero Neto
Mar 14, 2008·Current Protein & Peptide Science·Guangshun Wang
Nov 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyMichael Zasloff

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Citations

Sep 25, 2020·Antibiotics·Carlos José Correia SantanaMariana S Castro
Aug 17, 2020·International Journal of Molecular Sciences·Surajit Bhattacharjya, Suzana K Straus
Dec 24, 2020·International Journal of Molecular Sciences·Taylor Rounds, Suzana K Straus
Jul 18, 2021·Malaria Journal·Caroline Lin Lin ChuaAndrew Teo
Aug 8, 2021·International Journal of Molecular Sciences·Federica ArmasMarco Scocchi
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xinyu SongZhiyu He
Jul 2, 2021·Emerging Topics in Life Sciences·Derry K MercerDouglas Fraser-Pitt
Dec 10, 2021·Frontiers in Immunology·Dilraj KaurGajendra P S Raghava

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Methods Mentioned

BETA
amidation
nuclear magnetic resonance
phage-display
circular dichroism
acetylation
X-ray

Clinical Trials Mentioned

ISRCTN12149720
ISRCTN84220089
NCT03688971
NCT02576847
NCT02547441
NCT02576860
NCT03091426
NCT02596074
NCT03071679
NCT02571998

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