Strategies of hemopoietic stress adaptation within the medullary cavity

The Anatomical Record
D C GiulianiB S Morse

Abstract

Gravimetric determination of total bone water space was used as an index of available bone marrow space in mice following various specific stressors, i.e., splenectomy, hypoxia, bone fracture, and estrone-induced osteosclerosis. Data was corrected for bone weight and was reported as specific bone marrow volume (total bone water space/mg dry bone X 100). A direct relationship was observed between specific bone marrow volume and medullary hemopoietic activity induced by stress. Absolute and/or relative marrow space increased following splenectomy, hypoxia, and fracture. Osteosclerotic animals shift most hemopoietic activity from marrow to spleen, and splenectomized osteosclerotic animals become anemic. Both intact and splenectomized hypoxic animals develop increased specific bone marrow volume and successfully compensate for hypoxia with enhanced erythropoiesis. Animals sustaining a fracture callus increase both specific bone marrow volume and hemopoietic activity at the callus without an increase in hemopoietic demand. Increased specific bone marrow volume extends the marrow bone interface, where primitive stem cells accumulate, while expanding marrow stromal space, where stem cells lodge, proliferate and differentiate. Therefor...Continue Reading

References

May 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·H M Patt, M A Maloney
Mar 1, 1974·Cell and Tissue Kinetics·B S MorseE R Giuliani
Jul 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·R D LangeN R Dibelius
Apr 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D J Simmons
Jan 1, 1982·Journal of Cellular Physiology. Supplement·J E Till
Apr 1, 1981·Journal of Microscopy·D GreenM C Thorne
Jul 1, 1982·Cell and Tissue Kinetics·M C Mackey, P Dörmer
Jun 11, 1981·The New England Journal of Medicine·L G Raisz
Jul 1, 1958·British Journal of Haematology·G HUDSON

Citations

Sep 18, 2010·Calcified Tissue International·Takeshi MatsumotoKentaro Uesugi
Mar 3, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Clarisa BozziniCarlos E Bozzini
Aug 9, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ralph A MeyerMartha H Meyer

Related Concepts

Adaptation, Physiological
Skeletal Bone
Bone Marrow Diseases
Unigen
Hematopoiesis, Medullary
Mice, Inbred Strains
Splenectomy
Fracture

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