Strategies of hemopoietic stress adaptation within the medullary cavity

The Anatomical Record
D C GiulianiB S Morse


Gravimetric determination of total bone water space was used as an index of available bone marrow space in mice following various specific stressors, i.e., splenectomy, hypoxia, bone fracture, and estrone-induced osteosclerosis. Data was corrected for bone weight and was reported as specific bone marrow volume (total bone water space/mg dry bone X 100). A direct relationship was observed between specific bone marrow volume and medullary hemopoietic activity induced by stress. Absolute and/or relative marrow space increased following splenectomy, hypoxia, and fracture. Osteosclerotic animals shift most hemopoietic activity from marrow to spleen, and splenectomized osteosclerotic animals become anemic. Both intact and splenectomized hypoxic animals develop increased specific bone marrow volume and successfully compensate for hypoxia with enhanced erythropoiesis. Animals sustaining a fracture callus increase both specific bone marrow volume and hemopoietic activity at the callus without an increase in hemopoietic demand. Increased specific bone marrow volume extends the marrow bone interface, where primitive stem cells accumulate, while expanding marrow stromal space, where stem cells lodge, proliferate and differentiate. Therefor...Continue Reading


May 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·H M Patt, M A Maloney
Mar 1, 1974·Cell and Tissue Kinetics·B S MorseE R Giuliani
Jul 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·R D LangeN R Dibelius
Apr 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D J Simmons
Jan 1, 1982·Journal of Cellular Physiology. Supplement·J E Till
Apr 1, 1981·Journal of Microscopy·D GreenM C Thorne
Jul 1, 1982·Cell and Tissue Kinetics·M C Mackey, P Dörmer
Jun 11, 1981·The New England Journal of Medicine·L G Raisz
Jul 1, 1958·British Journal of Haematology·G HUDSON


Sep 18, 2010·Calcified Tissue International·Takeshi MatsumotoKentaro Uesugi
Mar 3, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Clarisa BozziniCarlos E Bozzini
Aug 9, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ralph A MeyerMartha H Meyer

Related Concepts

Adaptation, Physiological
Skeletal Bone
Bone Marrow Diseases
Hematopoiesis, Medullary
Mice, Inbred Strains

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.