Strategies to improve compliance with narcotic antagonists

The American Journal of Drug and Alcohol Abuse
T R Kosten, H D Kleber

Abstract

The pharmacologic promise of naltrexone has not been matched by therapeutic usefulness. Plagued by difficulties in the induction period and very high dropout, the drug remains limited to a very small segment of the opiate-addited population. Some programs have managed, however, to substantially improve on these problems and such strategies will be discussed. The paper will look at the different problems raised during the high dropout periods of induction, the first month of stabilization, and the later stages of maintenance. It will then focus on methods to deal with these problems. Strategies examined will include among others individual and group counseling, family and couples' therapy, and contingency contracting. Strengths and weaknesses of each of these both from our own 7 years of experience and in the literature will be examined.

References

Jan 1, 1978·Annals of the New York Academy of Sciences·H D Kleber, M S Gold
Sep 16, 1978·Lancet·M S GoldH D Kleber
Jul 6, 1978·Psychopharmacology·B K AlexanderP F Hadaway
Jan 1, 1978·The American Journal of Drug and Alcohol Abuse·M D StantonJ M Van Deusen
Jan 1, 1979·The American Journal of Drug and Alcohol Abuse·J GrabowskiS Steinberg-Donato
Dec 1, 1977·European Journal of Pharmacology·S R ChildersS H Snyder
Oct 1, 1977·The International Journal of the Addictions·H D Kleber
Jan 1, 1977·The American Journal of Drug and Alcohol Abuse·H D Kleber
Jan 1, 1978·The American Journal of Drug and Alcohol Abuse·S I SideroffM E Jarvik
Mar 1, 1976·Archives of General Psychiatry·R E MeyerH B McNamee
Aug 5, 1976·Nature·R Simantov, S H Snyder
Dec 1, 1976·Archives of General Psychiatry·S M MirinH B McNamee
Aug 1, 1975·Archives of General Psychiatry·L N RobinsD H Davis
Jul 28, 1975·JAMA : the Journal of the American Medical Association·E C Senay
Jan 1, 1976·The International Journal of the Addictions·J Spensley
Jan 1, 1974·The American Journal of Drug and Alcohol Abuse·P S PiersonH D Kleber
Jun 1, 1973·Archives of General Psychiatry·W R MartinP A Mansky
Jan 1, 1974·Archives of General Psychiatry·H D KleberD Sweeney
Mar 1, 1974·Psychological Review·R L Solomon, J D Corbit
May 17, 1980·Lancet·C E Riordan, H D Kleber
Jan 1, 1980·The American Journal of Drug and Alcohol Abuse·A J Schecter
Feb 1, 1983·The Journal of Nervous and Mental Disease·T R KostenH D Kleber
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·R B ResnickA M Washton
Feb 1, 1982·Archives of General Psychiatry·B J RounsavilleC Wilber
Nov 1, 1982·Archives of General Psychiatry·J F Maddux, D P Desmond
Nov 1, 1982·Comprehensive Psychiatry·T R KostenH D Kleber
Jan 1, 1982·The American Journal of Drug and Alcohol Abuse·T R KostenH D Kleber
Aug 1, 1981·Drug and Alcohol Dependence·L E HollisterH K Gillespie
Nov 1, 1981·Archives of General Psychiatry·K D Brownell, A J Stunkard
Sep 1, 1981·Drug and Alcohol Dependence·R F AntonH D Kleber
Jan 1, 1981·The American Journal of Drug and Alcohol Abuse·R GreensteinA Vittor
Sep 1, 1980·The American Journal of Psychiatry·A M Washton, R B Resnick
Aug 23, 1965·JAMA : the Journal of the American Medical Association·V P DOLE, M NYSWANDER

Citations

Sep 15, 2006·Psychopharmacology·Maria A SullivanSandra D Comer
Jan 1, 1989·Life Sciences·T R KostenC H Morgan
Sep 22, 2000·Peptides·Roberto CiccocioppoMaurizio Massi
Dec 24, 2002·Journal of Substance Abuse Treatment·Jami L RothenbergEdward V Nunes
Mar 21, 2003·Journal of Substance Abuse Treatment·Cindy Parks ThomasR M Swift
Aug 26, 1998·Journal of Pain and Symptom Management·P Compton
Jun 11, 2003·Journal of Consulting and Clinical Psychology·William Fals-Stewart, Timothy J O'Farrell
Jul 2, 2005·Journal of Psychiatric Practice·C J Welsh, J Liberto
Jun 24, 2008·Science & Practice Perspectives·T R Kosten, Tony P George
Aug 10, 2007·Expert Opinion on Investigational Drugs·Sandra D ComerGary Hulse
Jan 4, 2001·Substance Use & Misuse·B K Boyarsky, E F McCance-Katz
Apr 1, 1994·The International Journal of the Addictions·W DeJong
Jan 1, 1984·The American Journal of Drug and Alcohol Abuse·T R KostenH D Kleber
Jan 1, 1987·The American Journal of Drug and Alcohol Abuse·H D KleberT R Kosten
Jan 1, 1987·The American Journal of Drug and Alcohol Abuse·T R KostenH D Kleber
Mar 13, 2012·The American Journal of Drug and Alcohol Abuse·Stacey C SigmonG E Woody
Jun 1, 1991·The American Journal of Drug and Alcohol Abuse·T R KostenH D Kleber
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·D J RohsenowC A Eaton
May 15, 2012·Preventive Medicine·Anthony DeFulio, K Silverman
Sep 1, 1984·Comprehensive Psychiatry·T R KostenH D Kleber
Feb 1, 1990·Drug and Alcohol Dependence·T R KostenH D Kleber
May 1, 1988·British Journal of Addiction·E ViningH D Kleber
Jan 7, 2000·The Psychiatric Clinics of North America·J J Zealberg, K T Brady
Jan 1, 1985·Biological Psychiatry·H D KleberM Topazian
Jun 9, 2004·Journal of Substance Abuse Treatment·Evgeny M KrupitskyG E Woody
Jan 1, 1989·Nursing Science Quarterly·M A Compton
Nov 28, 1997·The British Journal of Psychiatry : the Journal of Mental Science·A SeoaneG Sobrepere
Jul 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·C Brewer

Related Concepts

Combined Modality Therapy
Life Style Induced Illness
Physeptone
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Trexan
Opioid-Related Disorders
Patient Non-Compliance
Dropouts
Research Activities
Social Networks

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Related Papers

The American Journal of Drug and Alcohol Abuse
R GreensteinA Vittor
European Psychiatry : the Journal of the Association of European Psychiatrists
M GutiérrezJ R de Apodaka
The Cochrane Database of Systematic Reviews
Marica FerriC A Perucci
The International Journal of the Addictions
E J CallahanR P Liberman
© 2021 Meta ULC. All rights reserved