PMID: 15250050Jul 14, 2004Paper

Strategies to improve dendritic cell-based immunotherapy against cancer

Yonsei Medical Journal
Si Young Song, Han-Soo Kim

Abstract

Dendritic cells (DCs) play a pivotal role in T cell-mediated immunity and have been shown to induce strong antitumor immune responses in vitro and in vivo. Various approaches utilizing different vaccine cell formats, cell numbers, vaccination schedule, site of vaccination and maturation stages of DCs were investigated worldwide. While clinical trials have demonstrated the safety of such strategies, the clinical outcome was less than expected in most cases. This is due to in part host immunodeficiency imposed by tumors and immunoediting of tumor cells. To overcome these obstacles, new approaches to improve DC-mediated immunotherapeutic strategies are under investigation. First, functional enhancement of monocyte-derived DCs can be generated with using flt3-ligand (FL). Second, diverse antigenic determinants from heat shock-treated tumor cells may improve the immunogenicity of DC-based vaccines. Third, inclusion of ex vivo expanded NK/NKT cells in DC-based vaccines could be beneficial since the bidirectional interaction of these two cell types are known to enhance NK cell effector function and to induce DC maturation. Application of these approaches may induce a broadened antitumor immune response and thereby promote the eliminat...Continue Reading

Citations

Apr 7, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jeanette E BoudreauYonghong Wan
Sep 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Aqeel JaveedMuhammad Mahmood Mukhtar
Jan 10, 2006·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Wing Keung ChanGodfrey Chi-Fung Chan
Mar 22, 2005·Bone Marrow Transplantation·J J Auletta, H M Lazarus
Nov 15, 2018·Medical Sciences : Open Access Journal·Yihai LiuBin Liu

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