Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases

Stem Cell Research & Therapy
Luisa H A SilvaPatricia R M Rocco

Abstract

Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. Nevertheless, even though MSC administration has been demonstrated to be safe in clinical trials, to date, few studies have shown evidence of MSC efficacy in respiratory diseases. The present review describes strategies to enhance the beneficial effects of MSCs, including preconditioning (under hypoxia, oxidative stress, heat shock, serum deprivation, and exposure to inflammatory biological samples) and genetic manipulation. These strategies can variably promote increases in MSC survival rates, by inducing expression of cytoprotective genes, as well as increase MSC potency by improving secretion of reparative factors. Furthermore, these strategies have been demonstrated to enhance the beneficial effects of MSCs in preclinical lung disease models. However, there is still a long way to go before such strategies can be translated from bench to bedside.

References

Sep 19, 2009·Respiratory Physiology & Neurobiology·Roberta M LassanceMarcelo M Morales
Oct 20, 2010·Stem Cells·Olin D LiangStella Kourembanas
Apr 17, 2012·Protein Science : a Publication of the Protein Society·Teresa C MoloneyEilís Dowd
Nov 23, 2012·Chest·Daniel J WeissDonald P Tashkin
May 10, 2013·American Journal of Respiratory Cell and Molecular Biology·Itziar Martínez-GonzálezJosep M Aran
Aug 16, 2014·BioResearch Open Access·Sébastien SartYan Li
Oct 3, 2014·Respiratory Research·Mariana A AntunesPatricia R M Rocco
Dec 11, 2014·The Journal of Biological Chemistry·Jing-Xian YangQing-Ping Wen
Dec 23, 2014·The Lancet. Respiratory Medicine·Jennifer G WilsonMichael A Matthay
May 20, 2015·Stem Cell Research & Therapy·Ying-Wei LanKowit-Yu Chong
Jan 29, 2016·QJM : Monthly Journal of the Association of Physicians·Jan StolkPieter S Hiemstra
Jan 29, 2016·PloS One·Lauralyn A McIntyreUNKNOWN Canadian Critical Care Translational Biology Group
Apr 15, 2016·Stem Cell Research & Therapy·Soraia C AbreuPatricia R M Rocco
Jul 14, 2016·Stem Cell Research & Therapy·Kenneth Andrew SinclairDaniel Charles Chambers
Sep 2, 2016·Stem Cell Research & Therapy·Jeffrey L SpeesCarl A Gregory
Oct 22, 2016·Experimental & Molecular Medicine·Yoonki HongYeon-Mok Oh
Mar 12, 2017·Cell·Robert A Saxton, David M Sabatini
Nov 17, 2017·Science Translational Medicine·Antonio GalleuFrancesco Dazzi

❮ Previous
Next ❯

Citations

Oct 5, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrea PorzionatoMaurizio Muraca
Jan 6, 2019·Bioscience Reports·Xing-Liang FanQing-Ling Fu
Apr 18, 2019·Human & Experimental Toxicology·S M ZakiM M Abdelmoaty
Dec 6, 2018·Current Stem Cell Research & Therapy·Alessandro Poggi, Maria R Zocchi
Nov 21, 2019·Journal of Cellular and Molecular Medicine·Lingfei ZhaoJianghua Chen
Sep 6, 2019·Cell Biology and Toxicology·Miquéias Lopes-PachecoPaolo Pelosi
Apr 23, 2020·Journal of Cellular and Molecular Medicine·Hua LiJunbo Ge
Aug 4, 2020·World Journal of Stem Cells·Hong-Long JiRun-Zhen Zhao
Sep 10, 2020·International Journal of Molecular Sciences·Hosanna Brave, Ronan MacLoughlin
Jul 14, 2020·Frontiers in Veterinary Science·Valeria CaffiClaudio Henríquez
Aug 28, 2020·Expert Opinion on Drug Delivery·Claire H MastersonJohn G Laffey
Jan 6, 2021·Expert Opinion on Biological Therapy·Nardeen KaderDeiary Kader
Feb 14, 2021·Npj Regenerative Medicine·Nisha DurandAbba C Zubair
Jan 22, 2021·Cellular & Molecular Biology Letters·Wenqing LiangXuerong Chen
Mar 27, 2021·Frontiers in Cell and Developmental Biology·Shengnan YangChen Wang
Apr 23, 2021·Tissue Engineering and Regenerative Medicine·Thi-Tuong Van NguyenPhuc Van Pham
May 28, 2021·Frontiers in Pharmacology·Linda Elowsson RendinGunilla Westergren-Thorsson
Jul 7, 2021·Cell Biochemistry and Function·Morteza HeidarzadehMahdi Ahmadi
Aug 28, 2021·International Journal of Molecular Sciences·Laura C BrennanRonan MacLoughlin
Oct 7, 2021·Clinical Microbiology Reviews·Timothy D ShawCecilia M O'Kane

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
flow cytometry
bronchoalveolar lavage

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.