Strategies to overcome immune ignorance and tolerance

Seminars in Cancer Biology
Miguel-Angel PeralesAlan N Houghton

Abstract

Cancer poses a difficult problem for immunotherapy because it arises from the host's own tissues. Many of the target antigens are tissue-specific molecules shared by cancer cells and normal cells. Thus, these are weak antigens that do not typically elicit immunity. In addition, tumors have several features that make their recognition and destruction by the immune system difficult. Despite these obstacles, several strategies for developing effective tumor immunity have been developed. Crucial to these approaches is the discovery and understanding of the molecular identity of antigens and the mechanisms involved in tumor immunity. In this review, strategies to overcome immune ignorance and tolerance are discussed.

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Citations

Jun 19, 2004·Hematology·David Z ChangMiguel-Angel Perales
Sep 10, 2003·Hematology/oncology Clinics of North America·Keith L KnutsonMary L Disis
Oct 21, 2005·Cytotherapy·G A Rizzuto, J D Wolchok
Oct 25, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Miguel-Angel Perales
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger K StrairEdmund C Lattime
Jul 1, 2003·Expert Review of Neurotherapeutics·Keith L KnutsonMary L Disis
Nov 17, 2015·Breast Cancer : Basic and Clinical Research·George R NahasPranela Rameshwar
Sep 24, 2004·Annals of Surgical Oncology·Miguel-Angel Perales, Jedd D Wolchok
Jun 30, 2004·Radiation Research·William H McBrideYu-Pei Liao
Jun 21, 2005·Springer Seminars in Immunopathology·Adrian F Ochsenbein
Nov 15, 2008·The Oncologist·Jedd D Wolchok, Yvonne Saenger
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei LuoSoldano Ferrone
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miguel-Angel PeralesMarcel R M van den Brink
Sep 18, 2018·Oncoimmunology·Katerina KachlerSusetta Finotto
Apr 30, 2014·Cancer Immunology Research·Gilson S BaiaGregory J Riggins
May 13, 2021·Cell Transplantation·Chi-Ping HuangChih-Rong Shyr
Feb 10, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard G VileJose S Pulido
Jul 13, 2004·Science·Ralph M Steinman, Ira Mellman

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