Strategies to overcome statin intolerance

Expert Opinion on Drug Metabolism & Toxicology
Aris P AgouridisDimitri P Mikhailidis

Abstract

This editorial discusses several options to overcome statin intolerance in clinical practice. For example, switching to a different statin, changing statin dosing, using lipid-lowering drugs other than statins (e.g., ezetimibe, bile acid sequestrants and fibrates, alone or in combination), or combining statins with other lipid-lowering drugs. The authors focus on the potential mechanisms involved in statin-related myopathy. New lipid-lowering drugs currently in development (e.g., cholesterol ester transfer protein inhibitors [anacetrapib] and proprotein convertase subtilisin/kexin 9 inhibitors) inhibitors may help in the management of statin intolerance while achieving low-density lipoprotein cholesterol targets as set out by the guidelines.

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Citations

Oct 6, 2015·Expert Opinion on Drug Safety·Aris P AgouridisMoses S Elisaf
Sep 7, 2016·Bulletin of Experimental Biology and Medicine·Z I Mikashinovich, E S Belousova
Jul 26, 2019·Expert Opinion on Pharmacotherapy·Niki KatsikiMaciej Banach
Jan 6, 2018·Expert Review of Clinical Pharmacology·Niki KatsikiDimitri P Mikhailidis
Sep 20, 2018·Hormones : International Journal of Endocrinology and Metabolism·Niki Katsiki, Dimitri P Mikhailidis

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