Strategies to overcome the ABO barrier in kidney transplantation

Nature Reviews. Nephrology
G A BöhmigThomas Wekerle

Abstract

Kidney transplantation across the ABO blood group barrier was long considered a contraindication for transplantation, but in an effort to increase donor pools, specific regimens for ABO-incompatible (ABOi) transplantation have been developed. These regimens are now widely used as an integral part of the available treatment options. Various desensitization protocols, commonly based on transient depletion of preformed anti-A and/or anti-B antibodies and modulation of B-cell immunity, enable excellent transplant outcomes, even in the long-term. Nevertheless, the molecular mechanisms behind transplant acceptance facilitated by a short course of anti-humoral treatment are still incompletely understood. With the evolution of efficient clinical programmes, tailoring of recipient preconditioning based on individual donor-recipient blood type combinations and the levels of pretransplant anti-A/B antibodies has become possible. In the context of low antibody titres and/or donor A2 phenotype, immunomodulation and/or apheresis might be dispensable. A concern still exists, however, that ABOi kidney transplantation is associated with an increased risk of surgical and infectious complications, partly owing to the effects of extracorporeal tre...Continue Reading

References

Nov 1, 1992·American Journal of Surgery·P W NelsonC F Bryan
May 17, 1990·Nature·F YamamotoS Hakomori
Aug 1, 1987·Biochemical Society Transactions·R Oriol
Sep 19, 1968·The New England Journal of Medicine·G M WilliamsF Milgrom
Jul 1, 1969·The Journal of Clinical Investigation·G F Springer, R E Horton
Jan 1, 1995·Annual Review of Immunology·J J MondC M Snapper
Jan 1, 1995·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·R MolliconeR Oriol
Mar 4, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·V Ravn, E Dabelsteen
Mar 15, 2001·The New England Journal of Medicine·L J WestJ G Coles
Dec 18, 2001·Journal of Clinical Apheresis·J H Yeh, H C Chiu
Apr 17, 2003·Transplantation·James M GloorMark D Stegall
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Walter D ParkMark D Stegall
Feb 1, 1955·The Journal of Clinical Investigation·D M HUMEG W THORN
May 8, 1959·Annals of the New York Academy of Sciences·G F SPRINGERM FORBES
Jul 23, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christopher J SonnendayRobert A Montgomery
Jan 6, 2005·Springer Seminars in Immunopathology·Nicole BaumgarthLeonore A Herzenberg
Sep 15, 2005·British Journal of Haematology·G StussiJ D Seebach
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dorry L SegevRobert A Montgomery
Apr 21, 2006·Xenotransplantation·Kota Takahashi, Kazuhide Saito
Jun 20, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M GloorM D Stegall
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasR A Montgomery
Jan 16, 2007·Transplantation·Bruce KaplanEnrico Benedetti

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Citations

Jun 22, 2016·Glycoconjugate Journal·Michael E BreimerSusann Teneberg
Jan 25, 2018·Somatosensory & Motor Research·Amalie Højmose SimoniParisa Gazerani
Sep 16, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Junji UchidaTatsuya Nakatani
Feb 22, 2017·The International Journal of Artificial Organs·Vladislav SemakViktoria Weber
Nov 22, 2019·World Journal of Transplantation·Maurizio Salvadori, Aris Tsalouchos
May 23, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sue ShinEun Youn Roh
Jun 10, 2021·Genes and Immunity·Sarah C Van AlstenCharles S Rabkin
Oct 24, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Annelies E de WeerdMarije C Baas

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