Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles

Anais Da Academia Brasileira De Ciências
Rodrigo Octávio M A DE Souza, Leandro S DE Mariz E Miranda

Abstract

The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substituted regioisomer. The unique properties of these N2-substituted 1,2,3-triazoles have stimulated synthetic efforts on the developments of methodologies capable of delivering it in high yield and selectivity. These efforts are the subject of the presented review.

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Citations

Nov 6, 2020·Organic & Biomolecular Chemistry·Vibha TiwariAnand Singh
Jun 8, 2021·Frontiers in Chemistry·Agnieszka StaśkiewiczRafal Latajka
Oct 12, 2021·The Journal of Organic Chemistry·Steven J Peters, Krutil Patel

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