Strategies used by helicobacter pylori to establish persistent infection

World Journal of Gastroenterology : WJG
Amin Talebi Bezmin Abadi

Abstract

Helicobacter pylori (H. pylori) is a Gram-negative and motile bacterium that colonizes the hostile microniche of the human stomach, then persists for the host's entire life, if not effectively treated. Clinically, H. pylori plays a causative role in the development of a wide spectrum of diseases including chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Due to the global distribution of H. pylori, it is no exaggeration to conclude that smart strategies are contributing to adaptation of the bacterium to its permanent host. Thirty-four years after the discovery of this bacterium, there are still many unanswered questions. For example, which strategies help the bacterium to survive in this inhospitable microniche? This question is slightly easier to answer if we presume the same clinical concept for both persistent infection and disease. Understanding the mechanisms governing H. pylori persistence will improve identification of the increased risk of diseases such as gastric cancer in patients infected with this bacterium. A well-defined and long-term equilibrium between the human host and H. pylori allows bacterial persistence in the gastric microniche; al...Continue Reading

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Citations

Jul 24, 2018·Journal of Medicinal Food·Erika Gomez-ChangIrma Romero
Sep 8, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Ante BubićIvana Leščić Ašler
May 16, 2020·Gastroenterology Research and Practice·Qingbin NiuBaoguang Hu
Dec 31, 2019·BioMed Research International·Eric Gyamerah OforiMichael Buenor Adinortey
Mar 14, 2020·International Journal of Molecular Sciences·Sandra Salillas, Javier Sancho
Jun 29, 2018·Journal of Pathogens·Amin Talebi Bezmin Abadi
Jul 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Qing LiuHua-Bin Li
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Dec 24, 2021·The Journal of International Medical Research·Guang ZhaoSu'nan Wang

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