Strategies Using Bio-Layer Interferometry Biosensor Technology for Vaccine Research and Development

Biosensors
Rejane L Petersen

Abstract

Bio-layer interferometry (BLI) real-time, label-free technology has greatly contributed to advances in vaccine research and development. BLI Octet platforms offer high-throughput, ease of use, reliability, and high precision analysis when compared with common labeling techniques. Many different strategies have been used to immobilize the pathogen or host molecules on BLI biosensors for real-time kinetics and affinity analysis, quantification, or high-throughput titer. These strategies can be used in multiple applications and shed light onto the structural and functional aspects molecules play during pathogen-host interactions. They also provide crucial information on how to achieve protection. This review summarizes some key BLI strategies used in human vaccine research and development.

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Citations

Feb 1, 2018·International Journal of Molecular Sciences·Yi-Chen ChanChun-Hung Lin
Dec 13, 2018·Organic & Biomolecular Chemistry·Shuang SunGonçalo J L Bernardes
Nov 26, 2020·Analytical and Bioanalytical Chemistry·Ross D OverackerSandra Loesgen
Oct 23, 2020·Sensors·Donggee RhoSeunghyun Kim
Mar 16, 2021·ACS Omega·Tamsyn StanboroughDeborah L Crittenden
Mar 20, 2021·Molecular Therapy. Methods & Clinical Development·Andreas L GimpelRichard D Braatz
Mar 20, 2021·Emerging Topics in Life Sciences·Mahalakshmi Harish, Prasanna Venkatraman
Mar 24, 2021·Scientific Reports·Marta Garrido-JareñoAntonio Pineda-Lucena
Aug 11, 2020·Pharmacology & Therapeutics·Claudia RiccardiDaniela Montesarchio
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Jan 7, 2022·Langmuir : the ACS Journal of Surfaces and Colloids·Israel AlshanskiShlomo Yitzchaik

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Methods Mentioned

BETA
Surface Plasmon
biosensor
equilibrium
enzyme-linked immunosorbent assays
ELISA
Epitope Capture
biosensors
gene knock-out
Antibody Capture
in vitro transcription

Software Mentioned

Mammoth
SPalign
align
TM
BLI
CLICK

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