PMID: 1207771Oct 1, 1975Paper

Strategy and tactics of chemotherapeutic drug development

Die Naturwissenschaften
F E Hahn

Abstract

Strategic approaches to generating chemotherapeutically active lead compounds are either empirical as in traditional synthetic programs or in the search for antibiotics; they are semiempirical as concerns the design of antimetabolites and more rational for the design of DNA-complexing drugs. The tactics of exploitation of active lead compounds in chemotherapeutic drug development involve molecular modification. This aims at either substances with greater activity and/or substances with improved pharmacokinetic parameters. From quantitative structure-activity relationships one might extrapolate to members of a chemical series with improved pharmacokinetic properties. Scientific advances render chemotherapy research more predictive and, hence, less empirical.

References

Jul 28, 1968·Journal of Molecular Biology·W Müller, D M Crothers
Oct 1, 1974·Electroencephalography and Clinical Neurophysiology·J W Steadman, R J Morgan
Jun 1, 1966·Journal of Molecular Biology·R RowndA Nakamura
Aug 1, 1973·Journal of Medicinal Chemistry·C HanschC H Won
Oct 1, 1967·Canadian Journal of Biochemistry·C J Abshire, R Pineau
Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·B K Bhuyan, C G Smith
Jan 1, 1969·Medicina Experimentalis. International Journal of Experimental Medicine·D M Aviado, H Reutter
Jul 1, 1957·Archives of Biochemistry and Biophysics·N SHARON, F LIPMANN
Jul 29, 1960·Biochimica Et Biophysica Acta·J M KIRK
Jan 15, 1963·Proceedings of the National Academy of Sciences of the United States of America·L S LERMAN
Jan 1, 1962·Cold Spring Harbor Symposia on Quantitative Biology·J CAIRNS
Oct 1, 1964·Journal of Cellular Physiology·L S LERMAN

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Citations

Feb 1, 1981·The Journal of protozoology·E A Steck

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