Strategy-based reasoning training modulates cortical thickness and resting-state functional connectivity in adults with chronic traumatic brain injury

Brain and Behavior
Kihwan HanDaniel C Krawczyk

Abstract

Prior studies have demonstrated training-induced changes in the healthy adult brain. Yet, it remains unclear how the injured brain responds to cognitive training months-to-years after injury. Sixty individuals with chronic traumatic brain injury (TBI) were randomized into either strategy-based (N = 31) or knowledge-based (N = 29) training for 8 weeks. We measured cortical thickness and resting-state functional connectivity (rsFC) before training, immediately posttraining, and 3 months posttraining. Relative to the knowledge-based training group, the cortical thickness of the strategy-based training group showed diverse temporal patterns of changes over multiple brain regions (pvertex < .05, pcluster < .05): (1) increases followed by decreases, (2) monotonic increases, and (3) monotonic decreases. However, network-based statistics (NBS) analysis of rsFC among these regions revealed that the strategy-based training group induced only monotonic increases in connectivity, relative to the knowledge-based training group (|Z| > 1.96, pNBS < 0.05). Complementing the rsFC results, the strategy-based training group yielded monotonic improvement in scores for the trail-making test (p < .05). Analyses of brain-behavior relationships reveal...Continue Reading

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Citations

Jan 24, 2018·Neurorehabilitation and Neural Repair·Karen CaeyenberghsPeter H Wilson
Aug 23, 2019·Neurorehabilitation and Neural Repair·Kihwan HanDaniel C Krawczyk
Jan 28, 2021·Military Medicine·Leanne R YoungSandra B Chapman
Oct 24, 2020·Contemporary Clinical Trials Communications·Ida BabakhanyanJason M Bailie
Mar 26, 2021·Neural Plasticity·Noelia Martínez-MolinaTeppo Särkämö
Apr 3, 2021·Frontiers in Public Health·Sandra Bond ChapmanJeffrey S Spence
Apr 15, 2021·Applied Neuropsychology. Adult·Anas Radi AlashramElvira Padua

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Key Resources (RRID) Mentioned

SCR_001847
SCR_005927

Software Mentioned

Freesurfer
Yeo
MATLAB
RsFC
SMART
SUMA
BrainNet Viewer

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.