Strategy use, planning, and rule acquisition deficits in spinocerebellar ataxia type 2 patients

Journal of the International Neuropsychological Society : JINS
Israel Vaca-PalomaresLuis Velázquez-Pérez

Abstract

Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization by testing the hypothesis that strategy, planning and rule acquisition capacities are affected in SCA2. Forty one patients with SCA2 were evaluated with the Spatial Working Memory (SWM), the Stockings of Cambridge (SOC), and the Intra-Extra Dimensional Shift (IED) tests of the Executive module of the Cambridge Neuropsychological Testing Automated Battery (CANTAB). Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) from the CANTAB memory module were also assessed to corroborate previous findings. Motor deterioration was measured using the Scale for the Assessment and Rating of Ataxia (SARA). We found significant SCA2 related deficits in strategy, planning, and rule acquisition. Our results also corroborated significant memory deficits in these patients with SCA2. Further analysis also showed that patients with large motor deterioration had poorer associative learning and spatial planning scores. Patients with SCA2 show strategy, planning, and rule acquisition deficits as revealed with the CANTAB battery. These deficits should be noted when planning an effective therapy for these patients.

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Citations

Jul 28, 2016·Behavioural Neurology·Zahid Sadek ChowdhuryMuhammad Shahdaat Bin Sayeed
Sep 27, 2018·The European Journal of Neuroscience·Amanda ChirinoJuan Fernandez-Ruiz
Mar 16, 2019·Cerebellum & Ataxias·Roberto Rodríguez-LabradaYanetza González-Zaldivar
Sep 29, 2017·Frontiers in Neurology·Luis C Velázquez-PérezJuan Fernandez-Ruiz
Oct 23, 2019·The Cerebellum·Angelo Fabio GiganteGiovanni Defazio
Mar 24, 2021·Parkinsonism & Related Disorders·Albert StezinPramod Kumar Pal
Jul 31, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Amanda Chirino-PérezJuan Fernandez-Ruiz

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