Stratification of type 2 diabetes based on routine clinical markers

Diabetes Research and Clinical Practice
Narges SafaiMartin Ridderstråle

Abstract

We hypothesized that patients with dysregulated type 2 diabetes may be stratified based on routine clinical markers. In this retrospective cohort study, diabetes related clinical measures including age at onset, diabetes duration, HbA1c, BMI, HOMA2-β, HOMA2-IR and GAD65 autoantibodies, were used for sub-grouping patients by K-means clustering and for adjusting. Probability of diabetes complications (95% confidence interval), were calculated using logistic regression. Based on baseline data from patients with type 2 diabetes (n = 2290), the cluster analysis suggested up to five sub-groups. These were primarily characterized by autoimmune β-cell failure (3%), insulin resistance with short disease duration (21%), non-autoimmune β-cell failure (22%), insulin resistance with long disease duration (32%), and presence of metabolic syndrome (22%), respectively. Retinopathy was more common in the sub-group characterized by non-autoimmune β-cell failure (52% (47.7-56.8)) compared to other sub-groups (22% (20.1-24.1)), adj. p < 0.001. The prevalence of cardiovascular disease, nephropathy and neuropathy also differed between sub-groups, but significance was lost after adjustment. Patients with type 2 diabetes cluster into clinically releva...Continue Reading

Citations

Jan 8, 2019·BMJ Open Diabetes Research & Care·Abdallah Ahmed GunaidAhmed Nasser Al-Radaei
May 18, 2020·Clinical and Experimental Pharmacology & Physiology·Mingchen ZhangHua Yao
Jun 9, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Giulia FerranniniAnna Norhammar
Oct 16, 2019·Frontiers in Endocrinology·Tarunveer S AhluwaliaPeter Rossing
Mar 13, 2021·BMC Medical Research Methodology·Jun Jie Benjamin SengLian Leng Low
Aug 20, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Laurent FauchierA John Camm
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Chang Liu, Yan V Sun
Sep 15, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Sam HodgsonHajira Dambha-Miller

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