Stratified Platelet-to-lymphocyte Ratio: A Novel Target for Prognostic Prediction of Hepatocellular Carcinoma after Curative Liver Resection

Journal of Clinical and Translational Hepatology
Gui-Qian HuangMing-Hua Zheng

Abstract

Background and Aims: Platelet-to-lymphocyte ratio (PLR) has been shown to predict prognosis of cancers. We aimed to evaluate the prognostic value of stratification of PLR in patients after curative liver resection (CLR) for hepatocellular carcinoma (HCC). Methods: A total of 1804 patients who underwent CLR for suspected HCC between January 2007 and January 2014 were screened for the study. All of the patients were categorized into equal tertiles according to the number of patients and the distribution of PLR. Prognostic significance was determined for overall survival (OS) and was assessed using Kaplan-Meier analysis. Univariate and multivariate Cox proportional hazard regression analyses were evaluated for association of all independent parameters with disease prognosis. Results: The optimal cut-off points of preoperative PLR were: (T1) 11.98-75.00, (T2) 75.00-113.33 and (T3) 113.33-567.50. There were obvious differences in each PLR tertile with mortality within 36 months of CLR (plog-rank < 0.001). Multivariable analysis suggested that the level of PLR (HR = 1.004, 95%CI: 1.001-1.008, p = 0.006), portal vein thrombosis (HR = 3.406, 95%CI: 1.185-9.794, p = 0.023), number of nodules (HR = 1.810, 95%CI: 1.345-2.437, p < 0.001), ...Continue Reading

References

Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MöhleS Rafii
Mar 17, 1999·Annals of Surgery·S T FanJ Wong
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyDavid M Nagorney
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chee Kiat TanDavid Machin
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Dec 16, 2006·World Journal of Gastroenterology : WJG·Masami Minagawa, Masatoshi Makuuchi
Mar 22, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G Morris-StiffK R Prasad
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Mar 11, 2010·Journal of Clinical Gastroenterology·Peter FerenciUNKNOWN World Gastroenterology Organization
Jun 29, 2010·American Journal of Surgery·Ismael Domínguez, Carlos Fernández-del Castillo
Jan 25, 2011·Nature Reviews. Cancer·Laurie J Gay, Brunhilde Felding-Habermann
Jul 22, 2011·Clinical Pharmacology and Therapeutics·S J ClarkeD C McMillan
Jan 21, 2012·International Journal of Cancer. Journal International Du Cancer·Daniel BuergyMarc A Brockmann
Jan 28, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-H ZhongG-B Wu
Oct 17, 2012·CA: a Cancer Journal for Clinicians·Mary Maluccio, Anne Covey
Oct 25, 2012·Journal of Gynecologic Oncology·Supachai RaungkaewmaneeThaovalai Thavaramara
May 2, 2013·Journal of Clinical Gastroenterology·Sahil Mittal, Hashem B El-Serag
Oct 15, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Quirino LaiJan Lerut
Jun 1, 2012·Liver Cancer·Do Young Kim, Kwang-Hyub Han
May 6, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Arnoud J TempletonEitan Amir
Nov 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xing LiXiao-Kun Ma
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 15, 2015·Asia-Pacific Journal of Clinical Oncology·Seyda GunduzHakan Bozcuk

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Methods Mentioned

BETA
surgical resection
CLIP

Software Mentioned

SPSS
MedCalc

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Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.