PMID: 9171377May 15, 1997Paper

strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila

Genes & Development
A MajumdarU Banerjee

Abstract

The dorsal/ventral (D/V) boundary functions as an organizer in the growth and patterning of the Drosophila wing disc and gives rise to the wing margin in the adult fly. Here we show that strawberry notch (sno) is a downstream component of the Notch signaling pathway and is important for the specification of this organizer. sno encodes a novel nuclear protein conserved in C. elegans, mouse, and humans. Mutations in wing margin genes interact dominantly with sno and loss of sno function results in loss of expression of wingless, vestigial, cut, and E(spl)-m8 at the D/V boundary. In regulating these genes, sno functions in close cooperation with Suppressor of Hairless and Hairless. Finally, sno has no role in lateral inhibition suggesting that it may contribute to the specificity between lateral and inductive Notch signaling pathways.

References

Nov 1, 1990·Developmental Biology·V Hartenstein, J W Posakony
Sep 20, 1988·Journal of Molecular Biology·N H Brown, F C Kafatos
Oct 22, 1982·Science·G M Rubin, A C Spradling
Sep 1, 1983·Cell·I S GreenwaldH R Horvitz
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
Sep 1, 1994·Mechanisms of Development·H K HingS Artavanis-Tsakonas
Oct 21, 1994·Cell·M E Fortini, S Artavanis-Tsakonas
Sep 1, 1993·Mechanisms of Development·M WehrliM Wilcox

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Citations

Jul 5, 2003·Experimental Hematology·Julie Lessard, Guy Sauvageau
Jul 31, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·S Netter, A Boivin
Mar 2, 2006·Molecular and Cellular Biology·Laurent SansregretAlain Nepveu
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George StratigopoulosRudolph L Leibel
Jun 2, 2009·Frontiers in Bioscience (Landmark Edition)·Neal I Alcalay, Gregory B Vanden Heuvel
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Volker Hartenstein, Andreas Wodarz
May 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ai TakanoYu Katsuyama
Oct 19, 2006·Biochemical and Biophysical Research Communications·Kousuke BabaYu Katsuyama
Jun 23, 2011·PLoS Computational Biology·David SprinzakMichael B Elowitz
Jun 6, 2014·PloS One·Franck Coumailleau, François Schweisguth
Oct 23, 2015·ELife·Prashanth R RaoThomas B Kornberg
Nov 8, 2006·Current Biology : CB·Jennifer L ChildressGeorg Halder
Feb 16, 2018·Genome Biology and Evolution·Julien Kincaid-SmithEve Toulza
Sep 6, 2001·Genesis : the Journal of Genetics and Development·B YedvobnickB Barrett
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karim C El KasmiPeter J Murray
Jun 10, 2021·Nature Communications·Thomas FriedrichIsabel Bäurle
Jun 24, 1998·Genes & Development·I Greenwald

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