PMID: 696705Jan 1, 1978Paper

Street heroin potency and deaths from overdose in San Antonio

The American Journal of Drug and Alcohol Abuse
D P DesmondA Trevino

Abstract

Disagreement over the mechanism of death in so-called heroin overdose has been noted in the medical literature for more than a decade. We studied the relationship between the potency of street heroin and the frequency of heroin overdose deaths in San Antonio in order to test the "pharmacologic overdose" hypothesis. We found a small, nonsignificant correlation (r=+.13) between monthly mean heroin dose and monthly number of heroin overdose deaths over a 5-year period. This low correlation contradicts findings of previous studies in Washington, D.C. and Atlanta, conducted over shorter periods of time, in which high positive correlations were found. The low correlation does not support the pharmacologic overdose hypothesis. Since there were confounding variables, the data do not refute the hypothesis. These variables include the use of alcohol and other depressants, hidden suicide, and reduced opioid drug tolerance due to institutional treatment.

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Citations

Jul 1, 1981·Journal of Psychoactive Drugs·F Goldman
Jun 7, 2003·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Shane Darke, Wayne Hall
Jul 1, 1982·American Journal of Public Health·G W JoeD D Simpson
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Apr 1, 2000·Contemporary Drug Problems·Avelardo ValdezAlice Cepeda
Oct 5, 1984·Science·A J Ruttenber, J L Luke

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