Abstract
Luminex single-antigen assay is a promising technique for determination of donor-specific antibodies (DSAs) in renal transplantation. Serum samples from living-relative renal recipients before and after renal transplantation were examined with the use of Luminex single-antigen assay. The impact of de novo DSAs on the early clinical outcomes of renal allograft was analyzed. Of the 61 patients included, 15 patients (24.6%) presented de novo DSA (4 class I, 4 class II, and 7 both classes) after transplantation, and the average (median) cumulative strength of DSA was 1,283 (range, 0-10,802) mean fluorescence index (MFI) for class I versus 1,324 (range, 0-14,985) MFI for class II (P > .05). Twelve (19.7%) of the 61 patients experienced a clinical/subclinical acute rejection (AR) episode within the 1st 2 years after transplantation. A clinical/subclinical AR episode was diagnosed in 40% of DSA(+) patients and 13.0% of DSA(-) patients (P < .05). DSA(+) patients who developed an AR episode had a higher mean cumulative MFI value (8,118.3 ± 5,287.4; range, 1,785-14,985) than patients who did not develop an AR episode (3,283.7 ± 2,601.0; range, 786-8,113; P < .05). Serum creatinine levels in the DSA(+) group were significantly higher than...Continue Reading
References
Jun 9, 2009·Transplantation·Patrizia AmicoStefan Schaub
Aug 22, 2009·Transplantation·Po-Chang LeeMatthew J Everly
Apr 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K BächlerS Schaub
Oct 26, 2010·Transplantation Proceedings·A I Sánchez-FructuosoR Valero
Mar 16, 2011·Transplantation·James E CooperAlexander C Wiseman
Jun 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J G O'LearyP I Terasaki
Aug 19, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Irma-Sofia A NtokouJohn N Boletis
Mar 21, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Jul 21, 2012·Transplantation·José Luis Caro-OleasAntonio Núñez-Roldán
Jan 9, 2013·Transplantation·Olivier BrugièreMarc Stern
Feb 6, 2013·Transplantation·Matthew J EverlyPaul I Terasaki
May 15, 2013·Transplant Immunology·Samantha J FidlerFrank T Christiansen
Jun 4, 2013·Transplantation Proceedings·M BanasikM Klinger
Jul 3, 2013·Clinical & Developmental Immunology·Atsushi YoshizawaSinji Uemoto
Oct 15, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Byung Ha ChungChul Woo Yang
Oct 18, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Georg DieplingerDirk L Stippel
Feb 11, 2014·Transplantation Proceedings·J HoshinoP I Terasaki
Citations
May 20, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Samir J PatelA Osama Gaber
Sep 8, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Sarah AbbesOluwatoyosi Onwuemene