Apr 24, 2020

Comparison of developmental genome expression in rodent molars reveals extensive developmental system drift.

BioRxiv : the Preprint Server for Biology
Marie SemonS. Pantalacci

Abstract

In evolution, it is widely believed that phenotypic changes root in developmental changes and phenotype conservation, in developmental conservation. Seeming phenotype conservation may however hide evolutionary changes in the underlying developmental mechanisms by which a trait is produced. This cryptic evolution is also called Developmental System Drift, and the extent of this phenomenon unclear. We used a well-characterized evo-devo model system, rodent molars, to test the correlation between phenotypic and developmental evolution. Between mouse and hamster, the morphology of the lower molars has much less diverged than the morphology of the upper molars. Is development accordingly more conserved? We compared molar crown formation with a standard approach, and with a tight transcriptome time-series to get a quantitative molecular profiling of developmental states. Our data identify common trends in the development of all molars. Upper and lower molars have their specificities since the early steps of morphogenesis, at the levels of the pattern of cusp formation, cellular composition and biased gene expression. The extent of difference in lower vs. upper molar development within one species does correlate with the extent of dif...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Study
Size
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Genes
Candidate Disease Gene
Research Personnel
FXR2 protein, mouse
Autistic Disorder
Fragile X Mental Retardation Protein

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research.

Related Papers

European Journal of Human Genetics : EJHG
Arija JansenDanielle Posthuma
Journal of Child Neurology
Manman NiuRandi J Hagerman
Archives of Disease in Childhood
A Redington, A Bush
© 2020 Meta ULC. All rights reserved