Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

Immunity
Rémy BosselutA Singer

Abstract

The present study has assessed the impact of the intracellular domains of CD4 and CD8 on positive selection and lineage direction of MHC class I-restricted thymocytes. Contrary to current presumption, we found that the CD4 tail promotes the generation of both CD4+ and CD8+ T cells without preference for the CD4+ T cell lineage. We also found that the identity of the coreceptor tail and hence the strength of coreceptor signaling determine the number of thymocytes undergoing positive selection but not their ultimate CD4/CD8 phenotype. These findings demonstrate that the strength of coreceptor signaling has a significant quantitative but not qualitative impact on positive selection and provide a simple explanation for the greater numbers of CD4+ than CD8+ T cells selected in the normal thymus.

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Citations

Mar 16, 2005·Current Opinion in Immunology·Karen Laky, B J Fowlkes
Feb 11, 2004·Nature Immunology·Xiaolong Liu, Rémy Bosselut
Sep 20, 2008·Nature Reviews. Immunology·Alfred SingerJung-Hyun Park
Mar 24, 2010·Annual Review of Immunology·Xi HeDietmar J Kappes
Dec 12, 2012·PloS One·Safak Isil CevikBatu Erman
Jul 1, 2009·Arthritis and Rheumatism·Joel D TaurogHolger M Reichardt
Dec 18, 2008·European Journal of Immunology·Satoshi KomaniwaKeiko Udaka
Feb 2, 2006·Immunological Reviews·Parinaz Aliahmad, Jonathan Kaye
Feb 12, 2010·Annals of the New York Academy of Sciences·Matthew L Bettini, Dario A A Vignali
Dec 17, 2014·Immunological Reviews·Giorgio InghiramiUNKNOWN AIRC 5xMille consortium ‘Genetics-driven targeted management of lymphoid malignancies’
Apr 19, 2016·Immunological Reviews·Ichiro Taniuchi
Jan 21, 2015·Immunology and Cell Biology·Charles SinclairBenedict Seddon
Oct 28, 2016·Scientific Reports·Kazumi OkamuraKoji Yasutomo
Apr 21, 2018·Annual Review of Immunology·Ichiro Taniuchi
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jenny S WongHsiu-Ching Chang
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anil ShankerAnne-Marie Schmitt-Verhulst
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Batu ErmanAlfred Singer
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Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuriko ItoToru Miyazaki
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Jul 25, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rui WangDavid H Margulies
Jan 6, 2021·Nature Communications·Mohammad M KarimiMatthias Merkenschlager

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