Streptococcal Bacteriocin-Like Inhibitory Substances: Some Personal Insights into the Bacteriocin-Like Activities Produced by Streptococci Good and Bad

Probiotics and Antimicrobial Proteins
John Robert Tagg

Abstract

The background to the discovery and commercial development of the first Streptococcus salivarius probiotic is documented. A 40-year search of the genus Streptococcus for a harmless natural antagonist of Streptococcus pyogenes had as its operational basis a simple deferred antagonism "fingerprinting" procedure, the application of which results in each tested strain being accorded an inhibitor production (P)-type and inhibitor sensitivity (S)-type profile. Systematic application of this schema has opened a "Pandora's Box" of novel streptococcal bacteriocin-like inhibitory substances (BLIS). The numerically prominent commensal S. salivarius is proposed to have a pivotal population-modulating role within the oral microbiota of humans. The probiotic strain S. salivarius K12 produces several megaplasmid-encoded BLIS including the lantibiotics salivaricin A and salivaricin B. Strain K12 and other BLIS-producing S. salivarius are currently in use or under development for application to the control of a variety of common maladies and infections of the human oral cavity.

References

Jul 1, 1978·Antimicrobial Agents and Chemotherapy·J R Tagg, L W Wannamaker
Jun 1, 1975·Antimicrobial Agents and Chemotherapy·J R TaggL W Wannamaker
Sep 30, 1972·Lancet·J R Tagg, A R McGiven
Nov 1, 1973·Infection and Immunity·W F Liljemark, R J Gibbons
Feb 1, 1980·Infection and Immunity·A Sklavounou, G R Germaine
Oct 1, 1983·Canadian Journal of Microbiology·W J Simpson, J R Tagg
May 7, 2003·Applied and Environmental Microbiology·Philip A Wescombe, John R Tagg
Feb 8, 2006·Applied and Environmental Microbiology·Ruth E WirawanJohn R Tagg
Apr 7, 2006·Applied and Environmental Microbiology·Jeremy P BurtonJohn R Tagg
Jul 28, 2006·Antonie van Leeuwenhoek·Philip A WescombeJohn R Tagg
Oct 3, 2006·Journal of Bacteriology·Nicholas C K HengGeoffrey R Tompkins
Oct 16, 2007·Applied and Environmental Microbiology·Nicholas C K HengJohn R Tagg
Jun 19, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D A PowerJ R Tagg

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Citations

Nov 10, 2013·Genome Announcements·Andrey V Karlyshev, Vyacheslav G Melnikov
Sep 3, 2009·Future Microbiology·Philip A WescombeJohn R Tagg
Oct 14, 2014·Frontiers in Cellular and Infection Microbiology·Juan Cristobal Jimenez, Michael J Federle
Jun 7, 2014·História, ciências, saúde--Manguinhos·Mauricio Lissovsky, Juliana Martins
Jun 1, 2010·Probiotics and Antimicrobial Proteins·Hikmate AbriouelAntonio Gálvez
Dec 13, 2012·Future Microbiology·Philip A WescombeJohn R Tagg
Jan 5, 2021·World Journal of Microbiology & Biotechnology·Laura García-CurielNorberto Chavarría-Hernández

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