Streptococcus halichoeri : Comparative Genomics of an Emerging Pathogen

International Journal of Genomics
Kirsi AaltonenTarja Sironen

Abstract

Streptococcus halichoeri is an emerging pathogen with a variety of host species and zoonotic potential. It has been isolated from grey seals and other marine mammals as well as from human infections. Beginning in 2010, two concurrent epidemics were identified in Finland, in fur animals and domestic dogs, respectively. The fur animals suffered from a new disease fur animal epidemic necrotic pyoderma (FENP) and the dogs presented with ear infections with poor treatment response. S. halichoeri was isolated in both studies, albeit among other pathogens, indicating a possible role in the disease etiologies. The aim was to find a possible common origin of the fur animal and dog isolates and study the virulence factors to assess pathogenic potential. Isolates from seal, human, dogs, and fur animals were obtained for comparison. The whole genomes were sequenced from 20 different strains using the Illumina MiSeq platform and annotated using an automatic annotation pipeline RAST. The core and pangenomes were formed by comparing the genomes against each other in an all-against-all comparison. A phylogenetic tree was constructed using the genes of the core genome. Virulence factors were assessed using the Virulence Factor Database (VFDB) c...Continue Reading

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Citations

Feb 14, 2021·Microorganisms·Daniela NumbergerPeter Valentin-Weigand
Aug 22, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jordan B GreenfieldJamie L Rothenburger

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Software Mentioned

PHYLIP
RAST ( Rapid Annotation using Subsystem Technology )
GBLOCKS
BioCircos
MUSCLE
blastp

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