Despite the enormous contributions of the bacterial paradigms Escherichia coli and Bacillus subtilis to basic and applied research, it is well known that no single organism can be a perfect representative of all other species. However, given that some bacteria are difficult, or virtually impossible, to cultivate in the laboratory, that some are recalcitrant to genetic and molecular manipulation, and that others can be extremely dangerous to manipulate, the use of model organisms will continue to play an important role in the development of basic research. In particular, model organisms are very useful for providing a better understanding of the biology of closely related species. Here, we discuss how the lifestyle, the availability of suitable in vitro and in vivo systems, and a thorough understanding of the genetics, biochemistry and physiology of the dental pathogen Streptococcus mutans have greatly advanced our understanding of important areas in the field of bacteriology such as interspecies biofilms, competence development and stress responses. In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism.
Adherence of Veillonella species mediated by extracellular glucosyltransferase from Streptococcus salivarius
Comparative acid tolerances and inhibitor sensitivities of isolated F-ATPases of oral lactic acid bacteria
Glucans synthesized in situ in experimental salivary pellicle function as specific binding sites for Streptococcus mutans
Human monocytes tumoricidal activity: the role of interferon-gamma and bacterial lipopolysaccharide in its stimulation, preservation and decay
The effect of lowering the pH on the composition and metabolism of a community of nine oral bacteria grown in a chemostat
Role of the Streptococcus mutans gtf genes in caries induction in the specific-pathogen-free rat model
Cariogenicity of Streptococcus mutans strains with defects in fructan metabolism assessed in a program-fed specific-pathogen-free rat model
Binding properties of streptococcal glucosyltransferases for hydroxyapatite, saliva-coated hydroxyapatite, and bacterial surfaces
Regulation of the gtfBC and ftf genes of Streptococcus mutans in biofilms in response to pH and carbohydrate
Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system
The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor
Role of urease enzymes in stability of a 10-species oral biofilm consortium cultivated in a constant-depth film fermenter
Effects of RelA on key virulence properties of planktonic and biofilm populations of Streptococcus mutans
The fabM gene product of Streptococcus mutans is responsible for the synthesis of monounsaturated fatty acids and is necessary for survival at low pH
Inducible antisense RNA expression in the characterization of gene functions in Streptococcus mutans
Co-ordinated bacteriocin production and competence development: a possible mechanism for taking up DNA from neighbouring species
Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2
Unmarked gene deletion mutagenesis of gtfB and gtfC in Streptococcus mutans using a targeted hit-and-run strategy with a thermosensitive plasmid
A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans
Streptococcus oligofermentans inhibits Streptococcus mutans through conversion of lactic acid into inhibitory H2O2: a possible counteroffensive strategy for interspecies competition
Construction of a counterselection-based in-frame deletion system for genetic studies of Streptococcus mutans
Streptococcal antagonism in oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans
Multiple sugar: phosphotransferase system permeases participate in catabolite modification of gene expression in Streptococcus mutans
Bacteria possessing two RelA/SpoT-like proteins have evolved a specific stringent response involving the acyl carrier protein-SpoT interaction
The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis
Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene
Independent gene duplications of the YidC/Oxa/Alb3 family enabled a specialized cotranslational function
Streptococcus mutans autolysin AtlA is a fibronectin-binding protein and contributes to bacterial survival in the bloodstream and virulence for infective endocarditis
A novel pheromone quorum-sensing system controls the development of natural competence in Streptococcus thermophilus and Streptococcus salivarius
Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms
Seryl-phosphorylated HPr regulates CcpA-independent carbon catabolite repression in conjunction with PTS permeases in Streptococcus mutans
Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface.
A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator
Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells
Role of glucosyltransferase B in interactions of Candida albicans with Streptococcus mutans and with an experimental pellicle on hydroxyapatite surfaces
The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life
The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm
Microfluidic study of competence regulation in Streptococcus mutans: environmental inputs modulate bimodal and unimodal expression of comX
Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomics
Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis
A QM/MM MD study of the pH-dependent ring-opening catalysis and lid motif flexibility in glucosamine 6-phosphate deaminase
Evaluation of the effects of Streptococcus mutans chaperones and protein secretion machinery components on cell surface protein biogenesis, competence, and mutacin production
Silver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effect
Mutan: A mixed linkage α-[(1,3)- and (1,6)]-d-glucan from Streptococcus mutans, that induces osteoclast differentiation and promotes alveolar bone loss
Protein relative abundance patterns associated with sucrose-induced dysbiosis are conserved across taxonomically diverse oral microcosm biofilm models of dental caries
Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants
Streptococcus mutans copes with heat stress by multiple transcriptional regulons modulating virulence and energy metabolism
A unique open reading frame within the comX gene of Streptococcus mutans regulates genetic competence and oxidative stress tolerance.
Deficiency of PdxR in Streptococcus mutans affects vitamin B6 metabolism, acid tolerance response and biofilm formation
Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone
Comparison of SEM and VPSEM imaging techniques with respect to Streptococcus mutans biofilm topography
α-Mangostin disrupts the development of Streptococcus mutans biofilms and facilitates its mechanical removal
An Essential Role for (p)ppGpp in the Integration of Stress Tolerance, Peptide Signaling, and Competence Development in Streptococcus mutans.
Functional amyloids in Streptococcus mutans, their use as targets of biofilm inhibition and initial characterization of SMU_63c.
Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms
Vitamin D Compounds Are Bactericidal against Streptococcus mutans and Target the Bacitracin-Associated Efflux System
Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium
Enhanced photodynamic therapy using light fractionation against Streptococcus mutans biofilm: type I and type II mechanism
Development of a tunable wide-range gene induction system useful for the study of streptococcal toxin-antitoxin systems
The copYAZ Operon Functions in Copper Efflux, Biofilm Formation, Genetic Transformation, and Stress Tolerance in Streptococcus mutans
Streptococcus mutans extracellular DNA is upregulated during growth in biofilms, actively released via membrane vesicles, and influenced by components of the protein secretion machinery.
Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo
Streptococcus mutans NADH oxidase lies at the intersection of overlapping regulons controlled by oxygen and NAD+ levels
Loss of NADH Oxidase Activity in Streptococcus mutans Leads to Rex-Mediated Overcompensation in NAD+ Regeneration by Lactate Dehydrogenase
Membrane proteomic analysis reveals overlapping and independent functions of Streptococcus mutans Ffh, YidC1, and YidC2.
A narrative review of the effects of sugar-sweetened beverages on human health: A key global health issue
Effect of brief periodic fluoride treatments on the virulence and composition of a cariogenic biofilm
Post-transcriptional regulation by distal Shine-Dalgarno sequences in the grpE-dnaK intergenic region of Streptococcus mutans.
Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteins
Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.
Dental acid etchant as a sensitizing agent in photodynamic therapy to reduce S. mutans in dentinal carious lesions
Cell wall associated protein TasA provides an initial binding component to extracellular polysaccharides in dual-species biofilm
Antimicrobial properties, compressive strength and fluoride release capacity of essential oil-modified glass ionomer cements-an in vitro study.
Efficiency of Bacillus subtilis metabolism of sugar alcohols governs its probiotic effect against cariogenic Streptococcus mutans
Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children
Curcuma longa L. (turmeric), Rosmarinus officinalis L. (rosemary), and Thymus vulgaris L. (thyme) extracts aid murine macrophages (RAW 264.7) to fight Streptococcus mutans during in vitro infection
Characterization of acid‑tolerance‑associated small RNAs in clinical isolates of Streptococcus mutans: Potential biomarkers for caries prevention
Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans
Association between exposure to household smoking and dental caries in preschool children: a cross-sectional study
Metabolic Modeling of Streptococcus mutans Reveals Complex Nutrient Requirements of an Oral Pathogen
The Role of Candida albicans Secreted Polysaccharides in Augmenting Streptococcus mutans Adherence and Mixed Biofilm Formation: In vitro and in vivo Studies.
The Antimicrobial Effect of Cold Atmospheric Plasma against Dental Pathogens-A Systematic Review of In-Vitro Studies.
Anticariogenic activities of Libidibia ferrea, gallic acid and ethyl gallate against Streptococcus mutans in biofilm model.
Biofilm & Infectious Disease
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.