Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis

The Journal of Infectious Diseases
Jurgen R PietDiederik van de Beek

Abstract

Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis. Pneumococci harboring these genes show increased growth in human blood and cerebrospinal fluid (CSF). Mouse models of meningitis and pneumonia showed that pneumococcal strains without arginine biosynthesis genes were attenuated in growth or cleared, from lung, blood and CSF. Thus, S. pneumoniae arginine synthesis genes promote growth and virulence in invasive pneumococcal disease.

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Citations

Dec 15, 2015·The Lancet Infectious Diseases·Merijn W BijlsmaDiederik van de Beek
Aug 21, 2016·Journal of Neuroinflammation·Kin Ki JimChristina M J E Vandenbroucke-Grauls
Aug 4, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J M CosterusD van de Beek
Nov 4, 2016·Nature Reviews. Disease Primers·Diederik van de BeekEelco Wijdicks
May 17, 2019·Nature Communications·John A LeesDiederik van de Beek

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