Streptococcus pneumoniae induces mast cell degranulation

International Journal of Medical Microbiology : IJMM
Giovanna BarbutiPasqualina Montemurro

Abstract

Streptococcus pneumoniae colonizes the nasopharynx of healthy human carriers, but occasionally can spread in the body causing severe diseases. The mucosa of the respiratory tract is enriched in mast cells, key players of the innate immune response. Here, we report on the interaction of various strains of S. pneumoniae with the mast cell line RBL-2H3. Live, but not heat-killed, bacteria were found to induce mast cell degranulation in a dose- and time-dependent manner, only partially controlled by cytosolic calcium, with no production of TNF-alpha and IL-6. Non-encapsulated pneumococcal strains exhibited different potencies in triggering mast cells. We propose here that the induction of mast cell degranulation by pneumococcal factors not accompanied by the production of pro-inflammatory cytokines may be a specific strategy elaborated by this bacterium to promote its own spreading from the respiratory mucosa into the environment.

References

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Citations

Nov 4, 2011·Immunologic Research·Jordan Wesolowski, Fabienne Paumet
May 16, 2014·The Journal of Infectious Diseases·Florry E van den BoogaardTom van der Poll
Jul 14, 2010·FEMS Immunology and Medical Microbiology·Giovanna BarbutiPasqualina Montemurro
Feb 24, 2018·Biochemical Society Transactions·Hao XuShuzo Sugita
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Glenn CruseAras Kadioglu
Feb 9, 2013·Expert Review of Clinical Immunology·Nikita H TrivediBernard P Arulanandam
Mar 30, 2020·Immunity, Inflammation and Disease·Karen M Garcia-RodriguezSilvia Bulfone-Paus
Jul 13, 2021·Frontiers in Immunology·Lubica DraberovaPetr Draber

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