Abstract
Streptococcus pneumoniae colonizes the nasopharynx of healthy human carriers, but occasionally can spread in the body causing severe diseases. The mucosa of the respiratory tract is enriched in mast cells, key players of the innate immune response. Here, we report on the interaction of various strains of S. pneumoniae with the mast cell line RBL-2H3. Live, but not heat-killed, bacteria were found to induce mast cell degranulation in a dose- and time-dependent manner, only partially controlled by cytosolic calcium, with no production of TNF-alpha and IL-6. Non-encapsulated pneumococcal strains exhibited different potencies in triggering mast cells. We propose here that the induction of mast cell degranulation by pneumococcal factors not accompanied by the production of pro-inflammatory cytokines may be a specific strategy elaborated by this bacterium to promote its own spreading from the respiratory mucosa into the environment.
References
Dec 18, 1992·Science·Y ZhangB A Jakschik
Mar 1, 1985·Reviews of Infectious Diseases·L A BurmanB Trollfors
Sep 1, 1995·Molecular Biology of the Cell·S A BarkerB S Wilson
Oct 1, 1995·Yeast·D C AmbergE M Beasley
May 2, 1996·Nature·R MalaviyaS N Abraham
Nov 17, 1999·Molecular Microbiology·F TonelloC Montecucco
Mar 20, 2001·Infection and Immunity·R HakenbeckA de Saizieu
Feb 21, 2002·Infection and Immunity·Alison R KerrTim J Mitchell
Feb 28, 2002·Trends in Immunology·Frédéric FégerMichel Arock
Aug 2, 2002·EMBO Reports·Anne Marie Di Guilmi, Andréa Dessen
Dec 20, 2002·Nature·Carl Nathan
Oct 2, 2004·Nature Reviews. Immunology·Jean S Marshall
Citations
Nov 4, 2011·Immunologic Research·Jordan Wesolowski, Fabienne Paumet
Nov 26, 2009·Infection and Immunity·Elin RönnbergGunnar Pejler
May 16, 2014·The Journal of Infectious Diseases·Florry E van den BoogaardTom van der Poll
Feb 6, 2014·Traffic·Jordan Wesolowski, Fabienne Paumet
Jul 14, 2010·FEMS Immunology and Medical Microbiology·Giovanna BarbutiPasqualina Montemurro
Feb 24, 2018·Biochemical Society Transactions·Hao XuShuzo Sugita
Apr 18, 2020·PloS One·Nobuo OkahashiShigetada Kawabata
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Glenn CruseAras Kadioglu
Feb 9, 2013·Expert Review of Clinical Immunology·Nikita H TrivediBernard P Arulanandam
Apr 5, 2018·Frontiers in Immunology·Johanna FritscherUwe Koedel
Mar 30, 2020·Immunity, Inflammation and Disease·Karen M Garcia-RodriguezSilvia Bulfone-Paus
Jul 13, 2021·Frontiers in Immunology·Lubica DraberovaPetr Draber