Streptococcus pneumoniae infection regulates expression of neurotrophic factors in the olfactory bulb and cultured olfactory ensheathing cells

Neuroscience
S Ruiz-MendozaWagner Baetas-da-Cruz

Abstract

Streptococcus pneumoniae is the causative agent of numerous diseases including severe invasive infections such as bacteremia and meningitis. It has been previously shown that strains of S. pneumoniae that are unable to survive in the bloodstream may colonize the CNS. However, information on cellular components and pathways involved in the neurotropism of these strains is still scarce. The olfactory system is a specialized tissue in which olfactory receptor neurons (ORNs) are interfacing with the external environment through several microvilli. Olfactory ensheathing cells (OECs) which also form the glial limiting membrane at the surface of the olfactory bulb (OB) are the only cells that ensheathe the ORNs axons. Since previous data from our group showed that OECs may harbor S. pneumoniae, we decided to test whether infection of the OB or OEC cultures modulates the expression levels of neurotrophic factor's mRNA and its putative effects on the activation and viability of microglia. We observed that neurotrophin-3 (NT-3) and glial cell-line-derived neurotrophic factor (GDNF) expression was significantly higher in the OB from uninfected mice than in infected mice. A similar result was observed when we infected OEC cultures. Brain-d...Continue Reading

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Citations

Nov 9, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lydiane AgierHélène Broutin
Feb 8, 2020·The Pediatric Infectious Disease Journal·Reshmi Mukerji, David E Briles
Apr 8, 2020·Cells·Lucas MorelTatiana Michel
Nov 9, 2016·Scientific Reports·Hugo Macedo-RamosWagner Baetas-da-Cruz
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Lynn NazarethJenny Ekberg

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