Streptococcus pneumoniae serotype 1 burden in the African meningitis belt: exploration of functionality in specific antibodies

Clinical and Vaccine Immunology : CVI
S BlumentalD Goldblatt

Abstract

Streptococcus pneumoniae serotype 1 (Sp1) constitutes an important cause of seasonal endemic meningitis in all age groups in the African meningitis belt. Despite a higher meningitis incidence, the Burkinabé population has an Sp1-specific antibody seroprevalence similar to that reported in the United Kingdom (UK). We aimed to establish whether the opsonophagocytic activity (OPA) of pneumococcal IgG naturally present in Burkina Faso differs from that seen in individuals in the UK and to compare the OPAs generated by natural and vaccine-induced immunity. Samples collected from pneumococcal vaccine-naive Burkinabé and UK subjects were matched for age (1 to 39 years) and anti-Sp1 IgG level, analyzed for OPA to 3 S. pneumoniae serotypes (1, 5, and 19A), and compared to postvaccine samples. Furthermore, the Burkinabé samples were assessed for IgG avidity and serotype-specific IgM concentrations. One hundred sixty-nine matched serum samples from both populations were selected. A greater proportion of Burkinabé subjects aged 1 to 19 years had functional Sp1 activity (OPA ≥ 8) compared to UK subjects (12% versus 2%, P < 0.001); however, the proportions were similar among adults (9%). The correlation between Sp1 IgG concentration and OPA ...Continue Reading

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Citations

Nov 9, 2016·BMC Infectious Diseases·Chrispin ChaguzaPAGe Consortium
Jul 7, 2017·Infectious Diseases·Christine WenneråsAnders Rosén
Apr 21, 2017·Clinical and Vaccine Immunology : CVI·Hugh AdlerJamie Rylance
Aug 11, 2015·Microbial Genomics·Jennifer E CornickPAGe Consortium

Related Concepts

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