Abstract
To examine the epidemiology of pneumococcal infection in Galicia (Spain) after the incorporation of the pneumococcal conjugate vaccine, and to determine serotype distribution, antibiotic susceptibility, risk factors and associated mortality in cases of invasive pneumococcal disease (IPD) during 2011 and 2012. All strains causing IPD in Galicia were studied. Serotyping was performed by agglutination and Quellung reaction. Antibiotic sensitivity to penicillin, cefotaxime, erythromycin, vancomycin, and levofloxacin was determined. The risk factors considered were chronic respiratory disease, heart disease, liver disease, kidney disease, diabetes mellitus, and HIV and non-HIV immunodeficiency. A total of 555 strains were collected, with 43 different serotypes being found. The most frequently isolated ones were: serotype3 (17.5%), serotype7F (12.6%), serotype19A (9.4%), serotype14 (4.1%), serotype6C (4.1%), serotype11A (4%) and serotype22F (3.8%). 57.1% of isolates were serotypes included in VNC-13V. Two non-penicillin-sensitive strains and two others were not sensitive to cefotaxime, and 24.7% of the strains were not susceptible to erythromycin (26.9% in 2011 and 22.5% in 2012). The case fatality rate was 16.5%, reaching 23.3% in p...Continue Reading
References
Dec 1, 1996·The Journal of Infectious Diseases·R DaganP Yagupsky
Apr 6, 2001·Lancet·W P HausdorffP R Paradiso
May 2, 2003·The New England Journal of Medicine·Cynthia G WhitneyUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
Jun 9, 2004·Journal of Clinical Microbiology·H-C SlotvedF Espersen
Feb 1, 2005·The Lancet Infectious Diseases·William P HausdorffKeith P Klugman
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen ArdanuyJosefina Liñares
Dec 29, 2009·The Journal of Infection·Caroline L TrotterElizabeth Miller
Jan 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zitta B HarboeHelle B Konradsen
Feb 6, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J LiñaresA Fenoll
Aug 19, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M WeinbergerMarc Lipsitch
Oct 5, 2010·The European Respiratory Journal·M W PletzK P Klugman
Jun 2, 2011·The Journal of Antimicrobial Chemotherapy·Dora RoloJosefina Liñares
Jun 21, 2011·Vaccine·M Angeles Gutiérrez RodríguezJuan Carlos Sanz Moreno
Jun 22, 2011·Vaccine·David CooperKathrin U Jansen
Dec 2, 2011·Enfermedades infecciosas y microbiología clínica·María Isabel MorosiniCarmen Torres
Mar 8, 2012·The Journal of Infection·Albert Jan van HoekElizabeth Miller
Aug 29, 2012·PloS One·Carmen ArdanuyJosefina Liñares
Mar 26, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C RockC Bergin
Sep 14, 2013·Paediatric Drugs·Greg L Plosker
Sep 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Manel LujánJordi Rello
Oct 15, 2013·Medicina clínica·Maria Teresa Pérez-RodríguezMaximiliano Álvarez-fernández
Citations
Sep 13, 2016·Human Vaccines & Immunotherapeutics
Apr 18, 2017·Atencion primaria·Carles LlorJesús Almeda
Dec 30, 2017·European Journal of Pediatrics·Amparo Escribano MontanerUNKNOWN EPI-Strep-064 study group
May 5, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Maitane Ibar-BariainAlicia Rodríguez-Gascón
Jun 10, 2021·Human Vaccines & Immunotherapeutics·Adoración Navarro-TornéCristina Méndez