Streptococcus pneumoniae Serotypes Identified in Mexican Children with Invasive Disease Before and After the Introduction of PCV7 (1993-2012)

Archives of Medical Research
Gabriela Echániz-AvilésSIREVA Network–Mexico

Abstract

Streptococcus pneumoniae is the leading cause of acute otitis media, pneumonia, meningitis, and sepsis. The heptavalent pneumococcal conjugate vaccine (PCV7) was incorporated into the national immunization program in Mexico in 2008. The aim of the study was to analyze the frequency of S. pneumoniae serotypes isolated from children ≤5 years of age with invasive diseases before and after the introduction of PCV7. Isolates from sterile fluids, tissues and other body fluids were obtained from 1993 to 2012. Isolates collected in hospitals for the surveillance network were sent to the Instituto Nacional de Salud Publica. Serotyping was done using the Quellung reaction. The pre-vaccination period was considered from 1993-2007. A total of 1346 isolates were collected during 1993-2012. In the pre-vaccination era, serotypes included in PCV7 accounted for 59.7% of the strains, whereas in 2012 they represented only 21% of cases. There was a significant decrease in all PCV7-included serotypes. A gradual increase of the 19A serotype was detected during the vaccination period from 7% in 2008 to 39% of the isolates in 2012. In this year, 29% of the serotypes causing invasive disease were not included in any of the pneumococcal conjugate vaccin...Continue Reading

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Citations

Dec 18, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Araceli Soto-NoguerónGabriela Echániz-Aviles
Jul 3, 2015·Archives of Medical Research·Viroj Wiwanitkit
Jan 27, 2017·Human Vaccines & Immunotherapeutics·Yadong A CuiPatricia Saddier
Feb 22, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·María Noemí Carnalla-BarajasUNKNOWN Grupo SIREVA-Mexico

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