Abstract
Streptococcus pneumoniae is the leading cause of acute otitis media, pneumonia, meningitis, and sepsis. The heptavalent pneumococcal conjugate vaccine (PCV7) was incorporated into the national immunization program in Mexico in 2008. The aim of the study was to analyze the frequency of S. pneumoniae serotypes isolated from children ≤5 years of age with invasive diseases before and after the introduction of PCV7. Isolates from sterile fluids, tissues and other body fluids were obtained from 1993 to 2012. Isolates collected in hospitals for the surveillance network were sent to the Instituto Nacional de Salud Publica. Serotyping was done using the Quellung reaction. The pre-vaccination period was considered from 1993-2007. A total of 1346 isolates were collected during 1993-2012. In the pre-vaccination era, serotypes included in PCV7 accounted for 59.7% of the strains, whereas in 2012 they represented only 21% of cases. There was a significant decrease in all PCV7-included serotypes. A gradual increase of the 19A serotype was detected during the vaccination period from 7% in 2008 to 39% of the isolates in 2012. In this year, 29% of the serotypes causing invasive disease were not included in any of the pneumococcal conjugate vaccin...Continue Reading
References
Oct 1, 1995·The Pediatric Infectious Disease Journal·G Echániz-AvilesF Solórzano-Santos
Jul 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G Echániz-AvilesJ L di Fabio
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G Echániz-AvilesA Tomasz
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Katherine A PoehlingWilliam Schaffner
Dec 3, 2008·Infection and Immunity·Merit MelinMerja Väkeväinen
Jun 6, 2009·Vaccine·Hanna Rinta-KokkoKari Auranen
Jun 11, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James D KellnerDavid W Scheifele
Aug 25, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Daniel J IsaacmanRalf R Reinert
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Nov 3, 2009·Vaccine·Marifi Pulido, Frank Sorvillo
Apr 7, 2012·Vaccine·Fernanda RodriguesAdam Finn
Jun 19, 2012·Journal of Infection in Developing Countries·Enrique Chacon-CruzGraciano Lopez-Espinoza
Jul 10, 2012·Vaccine·Mark van der LindenRüdiger von Kries
Sep 8, 2012·BMC Infectious Diseases·Catherine Weil-OlivierLorenzo Mantovani
Dec 25, 2012·Vaccine·Laurens LiesenborghsJohan Flamaing
Jul 16, 2013·Archives of Medical Research·Oscar Daniel Ortiz
Citations
Dec 18, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Araceli Soto-NoguerónGabriela Echániz-Aviles
Jul 3, 2015·Archives of Medical Research·Viroj Wiwanitkit
Oct 16, 2016·Bacteriophage·Luis A EstrellaBiswas Biswajit
Jan 27, 2017·Human Vaccines & Immunotherapeutics·Yadong A CuiPatricia Saddier
Feb 22, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·María Noemí Carnalla-BarajasUNKNOWN Grupo SIREVA-Mexico
Sep 29, 2020·The Lancet Infectious Diseases·Clara Inés AgudeloUNKNOWN SIREVA Working Group