Streptococcus suis Serotype 2 Infection Impairs Interleukin-12 Production and the MHC-II-Restricted Antigen Presentation Capacity of Dendritic Cells

Frontiers in Immunology
Corinne LetendreMariela Segura

Abstract

Streptococcus suis is an important swine pathogen and emerging zoonotic agent. Encapsulated strains of S. suis modulate dendritic cell (DC) functions, leading to poorly activated CD4+ T cells. However, the antigen presentation ability of S. suis-stimulated DCs has not been investigated yet. In this work, we aimed to characterize the antigen presentation profiles of S. suis-stimulated DCs, both in vitro and in vivo. Upon direct activation in vitro, S. suis-stimulated murine bone marrow-derived DCs (bmDCs) preserved their antigen capture/processing capacities. However, they showed delayed kinetics of MHC-II expression compared to lipopolysaccharide-stimulated bmDCs. Meanwhile, splenic DCs from infected mice exhibited a compromised MHC-II expression, despite an appropriate expression of maturation markers. To identify potential interfering mechanisms, Class II Major Histocompatibility Complex Transactivator (CIITA) and membrane-associated RING-CH (MARCH)1/8 transcription were studied. S. suis-stimulated DCs maintained low levels of CIITA at early time points, both in vitro and in vivo, which could limit their ability to increase MHC-II synthesis. S. suis-stimulated DCs also displayed sustained/upregulated levels of MARCH1/8, thus ...Continue Reading

References

Mar 1, 1996·The Journal of Experimental Medicine·B StockingerD Gray
Aug 26, 1998·FEMS Immunology and Medical Microbiology·Mariela SeguraMarcelo Gottschalk
Aug 24, 2004·Infection and Immunity·Mariela SeguraMartin Olivier
Dec 21, 2004·Springer Seminars in Immunopathology·Esther C de JongMartien L Kapsenberg
Feb 1, 2006·Immunobiology·Leandro J CarreñoAlexis M Kalergis
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·María C Domínguez-PunaroMarcelo Gottschalk
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aude De GassartEvelina Gatti
Jun 25, 2008·Infection and Immunity·María de la Cruz Domínguez-PunaroMarcelo Gottschalk
Oct 18, 2008·Immunobiology·Julia DriesenJoachim L Schultze
Jan 6, 2009·Immunological Reviews·Olivier JoffreCaetano Reis e Sousa
Dec 17, 2009·Cell Research·Jinfang Zhu, William E Paul
Jun 4, 2011·Veterinary Research·Marie-Pier LecoursMarcelo Gottschalk
Jun 22, 2011·Journal of Dental Research·J P ButcherS Culshaw
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daimon P SimmonsClifford V Harding
Apr 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dongchun LiangDeming Sun
Sep 13, 2012·Frontiers in Immunology·Susanne V SchmidtJoachim L Schultze
Sep 18, 2012·PloS One·Marie-Pier LecoursMarcelo Gottschalk
Nov 20, 2012·Oncoimmunology·Jacques ThibodeauRéjean Lapointe
Dec 12, 2012·Critical Reviews in Immunology·Claire HivrozArmelle Bohineust
Jan 10, 2013·Annual Review of Immunology·Janice S BlumPeter Cresswell
Mar 2, 2013·Frontiers in Immunology·Ghaith BakdashI Jolanda M de Vries
Jun 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hongjie PanXiao-Ping Zhong
Dec 7, 2013·Frontiers in Immunology·Kyung-Jin Cho, Paul A Roche
Mar 20, 2014·Infection and Immunity·Shaikh M AtifAndreas J Bäumler
Mar 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ranjna Madan-LalaJyothi Rengarajan
Aug 17, 2014·Current Opinion in Pharmacology·Javier Vega-RamosJose A Villadangos
Sep 10, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Vega-RamosJose A Villadangos
Jan 13, 2015·Current Opinion in Immunology·Justine D MinternJose A Villadangos
Apr 7, 2015·Seminars in Immunology·Maria Rescigno
Oct 16, 2015·Expert Review of Vaccines·Mariela Segura
Mar 19, 2016·Journal of Immunology Research·Damian ClarkeMariela Segura
Dec 2, 2016·Scientific Reports·Marie-Pier LecoursMariela Segura
Jul 15, 2017·Frontiers in Microbiology·Paul LemireMariela Segura

Related Concepts

C2ta protein, mouse
MARCH1 protein, mouse
Metazoa
Immune-Associated Antigens
Cell Differentiation Process
Veiled Cells
Mice, Inbred C57BL
Nucleolar Proteins
Streptococcal Infections
Trans-Activators

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.