PMID: 9423873Jan 10, 1998Paper

Streptokinase as a mediator of acute post-streptococcal glomerulonephritis in an experimental mouse model

Infection and Immunity
A NordstrandS E Holm

Abstract

Group A streptococcal infections are sometimes followed by the inflammatory kidney disease acute post-streptococcal glomerulonephritis (APSGN). To test the importance of streptokinase in the pathogenesis of this disease, isogenic strains of the nephritis isolate NZ131, differing only in the ability to produce streptokinase of the nephritis-associated ska1 genotype, were used for infection in a mouse tissue cage model for APSGN. Streptokinase production was found to be a prerequisite for the capacity of the strain to induce APSGN in mice. In addition, streptokinase was demonstrated in the kidneys of mice infected with the nephritogenic NZ131 and EF514 strains. After infection with the nonnephritogenic strain S84, neither streptokinase nor C3 deposition were observed. Deposition of streptokinase in the glomeruli was detected as soon as 4 days after infection. These findings provide support for the hypothesis that streptokinase initiates the nephritis process by glomerular deposition, which leads to local activation of the complement cascade. Detection of streptokinase in kidney tissue increased with the degree of glomerular hypercellularity. Thus, the severity of the pathological process may be a reflection of the degree of strep...Continue Reading

References

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Citations

Feb 13, 2001·Infection and Immunity·M S ChausseeJ M Musser
Feb 19, 2000·Scandinavian Journal of Infectious Diseases·A NordstrandS E Holm
Nov 18, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Larissa BurovaArtem Totolian
Jul 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T Matthew EisonRobert J Wyatt
Sep 30, 2008·Journal of Bacteriology·W Michael McShanDragutin J Savic
Sep 12, 2007·Seminars in Immunopathology·Saraladevi NaickerStewart Goetsch
Feb 22, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Larissa BurovaArtem Totolian
Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez
Sep 5, 2001·Kidney International·J Savill
Mar 16, 2019·Microbiology Spectrum·Horst Malke
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Sep 18, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chuan Chiang-Ni, Jiunn-Jong Wu

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