PMID: 6683437Jan 1, 1983

Streptokinase immobilization in insoluble carriers, and properties of the immobilized protein

Ukrainskiĭ biokhimicheskiĭ zhurnal
T V Grinenko, V G Tret'iachenko


Immobilization of streptokinase was performed by bromine cyan-activated cellulose and by aminoethyl cellulose using glutaric aldehyde and N-cyclohexyl-N'-[2-(4-morpholinyl)-ethyl-carbodiimide. The specific activator activity of the immobilized streptokinase is 70-100% of that of free streptokinase. In multiple application of the immobilized protein preparations streptokinase obtained by bromine cyan-activated cellulose is the most stable: it retains more than 40% of initial activity after 10 repeated applications. The immobilized streptokinase is shown to be more thermostable as compared to the soluble one.

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